Analysis Of Changes In Platelet Function During Myocardial Ischemia And Their Effects On Coronary Collateral Circulation And Cardiac Function In Dogs

It has been well known that changes of platelet function can exert an important role in development of angina pectoris and myocar-dial infarction. However, the characters of platelet changes in the coronary venous blood collected from ischemic myocardium after coronary occlusion, the mechanism underlying these changes, and the effects of platelet change on cardiac function are still unclear. In order to demonstrate whether inhibiting the platelet function can relieve the myocardial ischemia and analyze mechanism of platelet changes, we studied the relationship between the changes of platelet function and nervous-humoral factors following coronary occlusion, and observed the effects of platelet change on coronary collateral circulation, cardiac systolic and diastolic function, and electro-physiology of myocardial cells.Experiments were performed on anesthetized open-chest dogs(N= 126) and rabbits (N=90). The main subjects contain:1. Compare and observe the characters of platelet changes in venous blood collected from ischemic myocardium and the blood of systemic circulation.2. Investigate the role of cardiac sympathetic reflex induced by coronary occlusion in platelet changes by (1) topical application of lidocaine-soaked. pads to the ischemic area of the heart for bloc-...