Predictive Value Of Mean Platelet Volume/platelet Count For Prognosis In Acute ST-segment Elevation Myocardial Infraction

Objective:We aim to assess whether mean platelet volume/platelet count(MPV/PC)ratio is a useful marker to predict long-term prognosis in patients with ST-segment elevation myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Moreover,the prognostic accuracy of MPV/PC ratio is compared with MPV.Methods:1215 consecutive STEMI patients treated with P-PCI were considered.According to the admission MPV/PC values,the population was divided into two groups:high MPV/PC group(n=405,MPV/PC?0.055),and low MPV/PC group(n=810,MPV/PC<0.055).Primary end point was major adverse cardiovascular events(MACEs),a composite of cardiac mortality and nonfatal reinfarction.Results:Results.Conclusion:Multivariate analysis showed that high MPV/PC was an independent predictor of MACEs[HRs:1.121,95%CI:1.056-1.190,P<0.01],all-cause mortality[HRs:1.109,95%Cl:1.016-1.209,P=0.020],cardiac mortality[HRs:1.141,95%Cl:1.038-1.253,P=0.006],nonfatal myocardial reinfarction[HRs:1.148,95%Cl:1.044-1.262,P=0.004],and unplanned repeat revascularization[HRs:1.073,95%Cl:1.007-1.144,P-0.030],respectively.MPV/PC ratio has good accuracy for predicting MACEs(the area under the receiver operating characteristic curve:0.764),and the cut off value was 0.054 with a sensitivity of 0.813 and a specificity of 0.662.The discriminatory performance of MPV/PC ratio was better than MPV for predicting MACEs(MPV/P ratio vs.MPV:z=2.285,P =0.022),in STEMI patients undergoing P-PCI.