Mean Platelet Volume And Mean Platelet Volume Platelet Count Ratio Are Not Risk Predictors Of Periprocedural Myocardial Infarction In Patients Undergoing Coronary Angioplasty

Objective:Many studies have reported high values of peripheral blood platelet indices in prediction of thrombotic and inflammative events, Mean platelet volume and mean platelet volume platelet count ratio are the most important 2 predictors. Previous researches demonstrates that MPV does not predict the risk of PMI in patients undergoing PCI. The definition of PMI has been updated recent years, the aim of the study is to evaluate whether MPV and MVP/P is associated with increased risk of PMI post PCI.Method:We included 1120 patients undergoing PCI in SRRSH from August 2011 to March 2013,dividing them into 3 groups according to MPV (MPV< 8.5; 8.5-9.6;> 9.6) and MPV/P (MPV/P≤0.046; 0.046-0.064;> 0.064) separately. We evaluate the cardiac enzymes and ECG before PCI and at intervals from 6 to 48 h after PCI, then analyze the correlation between MPV (or MVP/P) and the risk of PMI post PCI.Results:MPV cannot predict the incidence of PMI (P=0.471;OR[95%CI]=1.092[0.860-1.386]), nor do MPV/P (P=0.435;OR[95%CI]=0.012[0.000-829.421]), Subgroup analysis confirmed no impact of MPV or MPV/P on periprocedural MI also in high-risk subsets of patients, such as female gender, elderly patients(>65), hypertension, diabetes, those with ACS at presentation, previous MI, previous PCI, or with renal failure.Conclusions:MPV and MVP/P cannot predict the risk of PMI in patients undergoing PCI in short term, but the valve in the long term need further study.