| Objective: Through this study,the distribution status of cancer-induced fatigue was understood,and the factors that may affect cancer-induced fatigue and the rules of traditional Chinese medicine for the treatment of cancer-induced fatigue,as well as clinical efficacy and safety observations,were analyzed,so as to provide a basis for alleviating cancer-induced fatigue.Methods:Using SPSS24.O software and EXCEL table,by collecting 304 patients with cancer-induced fatigue of malignant tumors hospitalized in the Affiliated Hospital of Liaoning University of Chinese Medicine from May 2022 to October2022 as the research subjects,using the short fatigue scale,KPS score,Piper fatigue scale,etc.to calculate the distribution status of cancer-induced fatigue,and using general data questionnaire,oncology data questionnaire,psychosocial questionnaire,etc.to collect basic information,age,Cancer,TCM type,frequency of use of Chinese medicine,liver and kidney function,white blood cells,CD8+T,CD4+T changes before and after treatment,etc.Establish Excel database and use SPSS24.0 software for statistical analysis.Descriptive statistical analysis was used for general data,and independent sample t-test and one-way ANOVA were used for the factors affecting cancer-related fatigue.Through the analysis of data,the influencing factors of cancer-induced fatigue in patients with malignant tumors and the characteristics and rules of Professor Yin Dongfeng and Director Gao Hong in the treatment of cancer-induced fatigue using traditional Chinese medicine were discussed.Outcome:1.Cancer-related fatigue: A total of 304 patients were included in this study,239 patients with CRF,and the incidence of CRF was 78.62%.The total fatigue score was4.75 ± 1.53,which was generally at moderate fatigue level.Among them,94 cases(30.92%)of mild fatigue had a total average score of 2.26±0.73,127 cases of moderate fatigue(30.92%),a total average score of 5.16 ± 0.69 of fatigue,and 18 cases of severe fatigue(5.92%),with a total average score of 7.53 ± 0.82.The scores for each fatigue dimension were:cognitive/emotional(4.9±2.23)>feeling(4.1±1.56)>behavior(3.7±1.83)> emotion(3.1±1.73).2.General data analysis:2.1 Compared with non-CRF groups: there were significant differences between previous antitumor therapy(P=0.036),KPS score(P<0.001),and anxiety/depression state(P<0.001).2.2 Comparison between groups with different degrees of fatigue: pathological type(P=0.027),anti-tumor mode(P=0.048),KPS score(P<0.001),and anxiety/depression state(P<0.001)were statistically different between the two groups.2.3 TCM Syndrome Analysis:2.3.1 There were 13 symptoms with a frequency of >30% of the 239 patients with cancer-induced fatigue,and the top seven symptoms with higher frequency were:fatigue,chest tightness,shortness of breath,insomnia,dreaminess,forgetfulness,fatigue,irritability,dry mouth/bitter mouth.2.3.2 The comparison results of the frequency distribution of deficiency syndrome in different degrees of cancer-induced fatigue showed that there were significant statistical differences between the CRF group and the non-CRF group in the < 0.001),blood deficiency(P<0.009)and Yang deficiency(P=0.038).Qi deficiency(P<0.001)was statistically different between groups with mild,moderate and severe fatigue.There were 35 cases of real syndrome in 65 non-CRF patients and 112 cases of mid-to-partial real syndrome in 239 patients with CRF,and there were no significant statistical differences between CRF and non-CRF groups(P>0.05)between different real syndromes in virtual and real inclusions through comparative analysis,and there were statistical differences between different fatigue groups(P=0.004).2.3.3 The statistical frequency analysis of drug prescriptions for 239 patients with cancer-induced fatigue was carried out,with a total of 128 flavors of drugs,and the top 20 drugs used in order were: Prince ginseng,Baishu,Astragalus,Poria,Fa Banxia,Bei Chaihu,Scutellaria baicalensis,Keel,Oyster,Half-branched lotus,White Flower Snake Tongue Grass,Coix Seed,Soil Porridge,Melon Mushroom,Licorice,Zhejiang Fritillary,Knotweed,and Xuan Ginseng.2.3.4 After oral administration of traditional Chinese medicine in 239 patients with CRF,there was no significant difference between AST,ALT,UR,CR and other liver and kidney function indexes compared with before treatment(P>0.05),but there was a significant difference in white blood cell count(P<0.05)compared with before treatment,which proved that the traditional Chinese medicine commonly in the treatment of cancer-induced fatigue had no obvious liver and kidney toxicity,but had certain clinical significance for improving white blood cells.After treatment,the immune function scores of 239 patients with cancer-induced fatigue were significantly higher than those before treatment(P<0.05).Conclusion:1.About 78.62% of patients in the study had cancer-induced fatigue,with moderate fatigue levels dominating,and cognitive/emotional fatigue was the most prominent in the fatigue dimension.2.CRF patients are mainly false evidence,among which there are more evidence of qi deficiency and blood deficiency,the degree of fatigue is positively proportional to the false evidence,and the false and real mixed evidence in severe fatigue shows an increasing trend,and the real evil is mainly qi stagnation and wet evil.3.The results of the study found that the influence of demographic data on cancer-induced fatigue was small;Whether chemotherapy/radiotherapy,depressive state,TCM weather deficiency,blood deficiency,yang deficiency,and KPS score may affect the occurrence of CRF;Anxiety/depression state,previous anti-tumor treatment,pathological type,KPS score,may be risk factors for aggravation of cancer-induced fatigue,and the occurrence of TCM symptoms of humid heat,qi deficiency,blood deficiency and yang deficiency is positively correlated with fatigue.4.Traditional Chinese medicine commonly used in the treatment of cancer-induced fatigue in the Oncology Department of the Affiliated Hospital of Liaoning University of Chinese Medicine can help improve the fatigue symptoms of patients and have high safety. |
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