Study On TCM Syndrome Factors And Related Factors Of Diabetic Peripheral Neuropath

Objective: In order to guide clinical dialectical treatment,we studied the distribution of TCM disease-related factors in 167 patients with DPN,and its correlation with sex,age,duration of diabetes,body mass index,physical and chemical examination results and other related factors.Methods: From January 2022 to December 2022,we collected the data of patients with DPN in the Department of Endocrinology of the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine by questionnaire survey.We filled in the basic information collection form and syndrome syndrome scale,and the obtained information was input into Excel software,and SPSS26.0 was used for statistical analysis.Results:(1)General information: a total of 167 patients were included in this study,including 85 males(50.9%)and 82 females(49.1%).The age ranged from 37 to 84 years,with an average age of58.35±8.705 years.The duration of diabetes ranged from 1 to 25 years(median,10 years).BMI ranged from 17.6 to 32.5kg/m2,with a median of 24.9kg/m2.Among the 167 patients,the top three limb symptoms with the highest frequency were numbness(167 cases),hypoesthesia(167cases),and cold sensation(42 cases).Limb symptoms were found in the limbs in 106 cases,limited to the upper limbs in 16 cases,and limited to the lower limbs in 45 cases.(2).Distribution of syndrome elements: By analyzing the syndrome factors of 167 patients included in the study,a total of 216 syndrome factors were extracted.The frequency from high to low was spleen(52.7%),kidney(50.3%),and liver(21.6%),and a total of 277 syndrome factors were extracted.The frequencies from high to low were phlegm(33.5%),dampness(31.7%),qi deficiency(22.8%),Yin deficiency(18.6%)and blood stasis(18.0%).(3)Correlation analysis: spleen was positively correlated with BMI(r=0.91),UA(r=0.676),TC(r=0.547),TG(r=0.525),LDL(r=0.419),and negatively correlated with HDL(r=-0.346);Kidney was positively correlated with age(r=0.914).Liver was positively correlated with gender(r=0.442)and age(r=0.510).Sputum was positively correlated with BMI(r=0.895),UA(r=0.685),TC(r=0.593),TG(r=0.518),LDL(r=0.44),and negatively correlated with HDL(r=-0.368).Wetness was positively correlated with BMI(r=0.836),UA(r=0.598),TC(r=0.483),TG(r=0.0.469),LDL(r=0.406),and negatively correlated with HDL(r=-0.307).Qi deficiency was positively correlated with age(r=0.865).Yang deficiency was positively correlated with age(r=0.869).Blood stasis was positively correlated with age(r=0.539)and course of disease(r=0.511).Heat was positively correlated with drinking history(r=0.843),and cold was negatively correlated with drinking history(r=-0.517).Conclusions: Most of the patients with diabetic peripheral neuropathy were middle-aged and elderly,without gender preference,with a disease duration of more than 5-10 years,and most of them were overweight and obese.The location factors of the disease are mainly in the spleen and kidney,especially in the kidney and liver in elderly patients.The main syndromes were phlegm,dampness,qi deficiency,Yin deficiency and blood stasis.Through correlation research,it was found that the age of patients with this disease was positively correlated with kidney syndrome factors,Yang deficiency syndrome factors,qi deficiency syndrome factors,blood stasis syndrome factors,and liver syndrome factors.The course of disease was positively correlated with blood-stasis syndrome factors.Drinking history was positively correlated with heat syndrome factors,and negatively correlated with cold syndrome factors.BMI,UA,TC,TG,LDL were positively correlated with spleen,dampness and phlegm syndrome elements,HDL was negatively correlated with spleen,dampness and phlegm syndrome elements.