| Purpose: To systematically evaluate the clinical efficacy of traditional Chinese medicine in treating painful diabetic peripheral neuropathy(PDPN).Using the method of TCM syndrome differentiation,this paper discusses the location and distribution characteristics of TCM syndrome elements of the disease,and discusses and analyzes the differences between syndrome elements and body mass index and physical and chemical indexes.Materials and methods:1.Search Chinese databases such as China Knowledge Infrastructure Project(CNKI),Wanfang Database and Chinese Sci-tech Journal Database by computer(database establishment-2022),and find out all randomized controlled trials(RCTs)of treating PDPN with compound Chinese medicine or combined western medicine.After screening,literature quality evaluation,and then extracting the meta included in the literature,the meta-analysis was carried out by using Review Manager5.4.1 software.2.Collect and analyze the medical records and physical and chemical indexes of 98 patients who meet the diagnosis of PDPN,and use the method of syndrome differentiation to count the distribution of TCM syndromes,and analyze the differences of body mass index and physical and chemical indexes of patients with different disease syndromes by statistical software SPSS26.0.Results:1.A total of 16 randomized controlled trials were included,including 1210 patients with PDPN.The methodological quality of the included literature is generally not high.Meta-analysis showed that compared with the control group treated with western medicine alone,the treatment of PDPN with compound Chinese medicine in the treatment group could significantly improve the clinical total effective rate,the conduction velocity of MNCV and SNCV in median nerve and common peroneal nerve,and reduce the VAS score and TCSS score.There were no serious adverse reactions in 16 RCTs,14 studies confirmed that no adverse reactions occurred,and 2 described the adverse reactions.2.A total of 98 subjects were included in the study,and there was no significant difference in gender,and there was no significant difference in gender distribution at all ages(P = 0.166 >0.05).In this study,there are 573 syndromes in PDPN patients,and the main syndromes are liver,spleen,stomach and kidney.There are 10 syndromes involved in diseases,which are blood stasis,yin deficiency,qi deficiency,qi stagnation,dampness,heat,yang deficiency,cold,blood deficiency and phlegm in turn.Most of the pathological syndromes are mixed with excess and deficiency,the solid syndromes are mainly blood stasis,and the deficiency syndromes are mainly yin deficiency.There were significant differences in BMI among qi deficiency,qi stagnation,dampness and phlegm compared with other syndromes(P < 0.05).Blood stasis and yin deficiency are most distributed between 7-9% of glycosylated hemoglobin;There are obvious differences between phlegm and other syndromes in blood lipid index(P < 0.05).Conclusion:1.Traditional Chinese medicine combined with western medicine can improve the clinical effective rate,the conduction velocity of median nerve and common peroneal nerve,and reduce the clinical scores of VAS and Toronto,which has obvious advantages in improving the quality of life of patients with PDPN.2.The main syndromes of 2.PDPN are liver,spleen,stomach and kidney;The main pathological syndromes are blood stasis,yin deficiency,qi deficiency and qi stagnation.Patients with qi deficiency,dampness and phlegm syndrome elements show that the greater the body mass index value;The main syndromes of blood stasis and yin deficiency are more common in glycosylated hemoglobin level of 7-9%;Phlegm syndrome elements are related to dyslipidemia. |
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