| Objective: This study through to the spleen and kidney Yang deficiency type puberty to study the insulin resistance in patients with polycystic ovary syndrome,observe the kidney and spleen phlegm weeks method sex hormone levels in patients with the disease,fasting glucose,fasting insulin,insulin resistance index,menstrual cycle and TCM syndrome score,the influence of spleen phlegm zhichuan method to the clinical efficacy of treatment of adolescent polycystic ovary insulin resistance and expand new solutions and ideas for clinical and research.Methods: Collected in December 2018 to July 2019 in rui kang affiliated hospital of guangxi medical university during gynecological clinic patients,screening accord with standard of this study spleen kidney Yang deficiency phlegm wet adolescent polycystic ovary syndrome,a total of 60 patients with insulin resistance,according to the doctor order according to random number table method were randomly divided into Chinese medicine group and western medicine control group,30 cases in each group.Group spleen phlegm zhichuan adjustable weeks method is used to Chinese medicine,western medicine control group to the metformin hydrochloride zyban,treatment for 3 months,were observed before and after treatment clinical curative effect,menstrual cycle,TCM syndrome integral,and adverse reactions,detection of two groups before and after the treatment of sex hormone level,fasting glucose,fasting insulin,insulin resistance index changes,use SPSS22.0 statistical software,statistical analysis of the collected data,the objective to determine the clinical curative effect.Results:(1)Total clinical efficacy: After the course of treatment,the total effective rate of the treatment group was 86.67%;The total effective rate of the control group was 68.97%.After statistical analysis,there was no statistically significant difference in the total clinical efficacy between the two groups after treatment(P>0.05);(2)TCM syndrome score: The difference between the two groups before and after treatment was statistically significant(P<0.05),indicating that the TCM clinical syndromes of both groups could be significantly improved after treatment.After treatment,the difference between the two groups was statistically significant(P<0.05),indicating that in terms of TCM clinical syndrome improvement,the TCM treatment group was significantly better than the Western medicine control group.(3)Comparison of fasting insulin and insulin resistance index between the two groups before and after treatment showed statistically significant difference(P<0.05).There was no statistically significant difference in serum glucose between the two groups before and after treatment(P>0.05),indicating that both groups could improve insulin resistance index by reducing fasting insulin.After treatment,there was no statistically significant difference in fasting glucose,fasting insulin and insulin resistance index between the two groups(P>0.05),indicating that there was no significant difference in the efficacy of improving fasting insulin and insulin resistance index between the two groups.(4)The two groups before and after treatment serum hormones LH,T value and the horizontal contrast,LH/FSH ratio difference was statistically significant(P<0.05),two groups before and after treatment serum FSH contrast,there was no significant difference(P>0.05),showed that both groups can reduce the serum hormones LH and T value,and the level of LH/FSH ratio,and mainly through the lower levels of LH,so as to improve the level of LH/FSH ratio.After treatment,the levels of serum hormone LH,T value and LH/FSH ratio in the two groups were compared,and the difference was statistically significant(P<0.05),indicating that the treatment group was better than the control group in improving the levels of LH,T value and LH/FSH ratio.(5)Analysis of drug safety: No drug allergic reaction occurred in the two groups during treatment,and no abnormalities were found in liver and kidney function,blood,urine,stool routine and electrocardiogram after treatment.Conclusion: The method of tonifying kidney,strengthening spleen and eliminating phlegm and regulating the weeks is effective and safe in the treatment of insulin resistance in adolescent polycystic ovary syndrome.It is better than metformin in improving TCM syndromes,improving LH,T value and LH/FSH ratio,and is an effective TCM treatment for insulin resistance in adolescent polycystic ovary syndrome,which is worthy of further clinical promotion and application. |
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