| Background:Acne vulgaris is a common skin disease that can affect the appearance of patients,with complex etiology and recurrence after treatment often causing great distress to patients.Traditional chinese medicine has a long history in the treatment of acne.with obvious effects of the rich and diverse treatment methods,including oral prescription,external ointment,traditional chinese medicine facial mask,and acupuncture,etc..Chen Tongyun,chinese medicine master,and her disciple,professor Qu Jianhua,are representative inheritors of the Yanjing Zhao dermatology school.They not only inherited the academic ideas of the Yanjing Zhao dermatology school,but also formed their own academic characteristics through continuous clinical practice with particularly skillness in the diagnosis and treatment of cosmetic skin diseases.Their academic ideas are worth learning and inheriting for future generations.With the rapid development of modern medical technology and the continuous deepening of research in skin physiology,many scholars have found that the destruction of skin barriers is closely related to the occurrence of acne.And some researchers abroad have also found through prospective research that,on the basis of adhering to drug treatment,the barrier repair treatment with skin care products of cleaning and moisturizing is a key factor in the clinical improvement of mild to moderate acne.Therefore,for acne patients,in addition to medication treatment,daily skin care is also very important.Traditional chinese medicine plays an important role in the research and development of skincare products with richness in chinese herbal extracts,which have attracted much attention due to their natural,safe,and stable effects.Chen Tongyun,a master of traditional Chinese medicine,donated her clinical experience and formula accumulated for many years to Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University for free.With the help of the hospital,she transformed her experiences and research achievements into the natural herbal medicine,namely,Jinhua refreshing face cream.Objective:①To explore and analyze the outpatient prescriptions of professor Chen Tongyun and Qu Jianhua on the treatment of acne vulgaris,for their medication patterns and clinical experience,to facilitate systematic summary and learning of their academic ideas.②To observe and safely evaluate the auxiliary effect of Jinhua refreshing face cream on mild to moderate acne vulgaris with the type of hot-humid lung-stomach and its impact on skin barrier function indicators of patients,further optimize the Traditional Chinese Medicine(TCM)Diagnosis and Treatment Plan of acne,and provide programs for daily skin care of acne patients.Methods:①We collected 100 outpatient prescriptions from professor Chen Tongyun and professor Qu Jianhua for the treatment of acne vulgaris,and analyzed the importance level,synergistic and mutually exclusive relationship,and clustering of traditional chinese medicine for conclusion through the FangNet analysis system built into the integrated platform for inheriting famous doctors.②Randomized controlled trial design was adopted to include patients with mild to moderate acne of hot and-humid lung-stomach type,and they were randomly divided into the test group and the control group.The test group took Qu Jianhua’s empirical formula of dehumidifying,twice a day,with Jinhua refreshing face cream twice a day as an assistant;while the control group received only oral administration of Qu Jianhua’s empirical formula of dehumidifying twice a day.Both groups were treated continuously for 4 weeks,and underwent score evaluation of acne symptom,visia testing,and skin barrier function index testing on the 0th and 28th days.The data were recorded and analyzed to draw conclusions.Results:①Professor Chen Tongyun’s 100 prescriptions involve a total of 103 traditional Chinese medicines.According to the topological center score,20 core traditional Chinese medicines were found,with the top 10 being capillary artemisia,forsythia suspensa,salvia miltiorrhiza,wild chrysanthemum,ligusticum wallichii,angelica sinensis,polygonum cuspidatum,phellodendron,radix stemonae,and coptis chinensis;8 pairs of commonly used drugs are angelica sinensis-ligusticum wallichii,ligusticum wallichii-salvia miltiorrhiza,angelica sinensis-salvia miltiorrhiza,radix stemonae-polygonum cuspidatum,salvia miltiorrhiza-coptis chinensis,phellodendron-coptis chinensis,coptis chinensis-ligusticum wallichii,coptis chinensis-angelica sinensis;the cluster analysis shows that professor Chen Tongyun’s basic formula for treating acne is capillary artemisia,forsythia suspensa,salvia miltiorrhiza,wild chrysanthemum,angelica sinensis,ligusticum wallichii,coptis chinensis,phellodendron,radix stemonae,polygonum cuspidatum,and rhizoma smilacis glabrae.Professor Qu Jianhua’s 100 prescriptions involve a total of 101 drugs.According to the topological center score,a total of 16 core traditional Chinese medicines were found,with the top 10 being salvia miltiorrhiza,forsythia suspensa,honeysuckle,capillary artemisia,scutellaria baicalensis,ligusticum wallichii,dandelion,angelica sinensis,lotus leaves,and fritillaria thunbergii;4 pairs of commonly used drugs are capillary artemisia-forsythia suspensa,scutellaria baicalensis-capillary artemisia,angelica sinensis-ligusticum wallichii,and angelica sinensis-scutellaria baicalensis;the cluster analysis shows that professor Qu Jianhua’s basic formula for treating acne is salvia miltiorrhiza,forsythia suspensa,honeysuckle,capillary artemisia,scutellaria baicalensis,angelica sinensis,and ligusticum wallichii.②A total of 24 patients,all female,aged 22-34,were included in this trial.During the follow-up process,3 cases were lost due to delayed follow-up.After 4 weeks of treatment,the total effective rate of the test group was 91.67%,with the control group being 88.89%;the test and control group both showed statistically significant differences in TEWL value,skin fat content,skin water content,and red zone before and after treatment(P<0.05);there was a statistically significant difference in TEWL value,skin fat content,skin water content,red zone,and baseline difference between the test group and the control group(P<0.05).Conclusions:①Professor Chen Tongyun believes that the common core pathogenesis of acne is "heat,toxin,humidity,and stagnation".When treating acne,the main approach is to clear the heat and toxin in the lungs and stomach,supplemented by dehumidification,invigoration the circulation of blood,activation of the Qi,and dissipation blood stasis.Medication should focus on clearing the lung-stomach heat and regulating the liver and spleen.While Professor Qu Jianhua believes that the pathogenesis of acne is based on humidity and heat,with stasis as the symptoms.When treating acne,the main treatment method is to remove heat and dampness,supplemented by symptoma-curing methods such as invigorating the circulation of blood,dissipation blood stasis,soothing the liver and promoting Qi,which emphasizes the care of the spleen and stomach.②The dehumidifying prescription of acne combined with Jinhua refreshing face cream or used alone in the treatment of acne vulgaris with lung-stomach damp-heat syndrome both has good effects on similar clinical efficacy,lower TEWL,reduction of the skin fat content,increase of skin water content,and reduction of the red zone,in which the prescription combined with Jinhua refreshing face cream is superior to the prescription used alone.Jinhua refreshing face cream has a certain auxiliary treatment effect on acne of lung-stomach damp-heat type,and has no obvious side effects in safety,which can provide a new method for clinical treatment of acne vulgaris and daily skin care of acne patients. |
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