| ObjectiveThrough the use of complex network data mining methods,explores and analyzes the treatment ideas and effective core prescriptions of the famous TCM doctor Chen Tongyun in acne treatment based on the theory of "spleen rising and stomach descenging",to provide objective academic data and basis for inheriting and learning Professor Chen’s thoughts and experiences.MethodsA total of 498 cases of acne patients treated in Chen Tongyun famous TCM outpatient Clinic from January 2018 to December 2021 were derived from his outpatient system of Beijing Hospital of Traditional Chinese Medicine.According to the inclusion and exclusion criteria,48 cases that did not meet the criteria were excluded,and a total of 450 cases were included.Based on the actual clinical diagnosis and treatment database of 450 patients,through the method of complex network data mining,this paper summarized the syndrome differentiation and classification rules and effective core prescriptions of Professor Chen in acne treatment.Result(1)A total of 450 acne patients were included in this study,including 79 males and 3 71 females,with the age ranging from 10 years old to 49 years old.The main manifestations of skin lesions were red papules(20%),acne(19%),excessive oil(18%),pustules(14%).The main parts of skin lesions were cheeks(28%),perioral parts(23%)and forehead parts(20%).The main symptoms include dry stool(9%),irregular menstruation(9%),abdominal distension(7%),irritable temper(6%),poor appetite(6%),and menstruation(5%).Tongue and pulse mainly include:red tongue(15%),pale red tongue(10%),white and greasy tongue(8%),white tongue(7%),smooth pulse(6%),thin pulse(6%),yellow and greasy tongue(6%),pulse string(6%).The main types of syndrome were:gastrointestinal dampness-heat syndrome(32.95%),liver qi stagnation syndrome(32.50%),phlegm clotting and blood stasis syndrome(15.91%),spleen deficiency and dampness accumulation syndrome(7.73%),lung meridian blood-heat syndrome(5.91%),Chong-ren unregulated syndrome(2.73%),deficiency of mid-yang syndrome(2.27%).(2)Complex network analysis results:The main skin lesions of acne:excessive facial oil production,red pimples,pimples,pustules,nodules.A total of 140 TCM were included in this study.Among them,the top 17 kinds of Chinese herbs were oriental wormwood,ligusticum chuanxiong,salvia miltiorrhiza,angelica,phellodendron,forsythia,polygonum cuspidatum,wild chrysanthemum,baibu,coptis chinensis,soil poria,north bean root,zeeland,lotus leaf,rhubarb,poria,north bupleurum.The main syndroms of gastrointestinal dampness-heat syndrome are new skin lesions or recurrence,red papules on the face,and increased facial oil production.The core prescription is mainly composed of heat-clearing and dehumidification related drugs.The main syndromes of spleen deficiency and dampness include pale red papules,acne,facial oil,nodules,pustules,abdominal distension,dilatancy,fatigue,and unformed stool in some patients.The core prescription is mainly composed of drugs related to strengthening spleen and dampness.The main syndromes of phlegm coagulation and blood stasis are dark red papules,nodules,cysts,accompanied by pustules,acne,dull color,scar,and skin pain.The core prescription is mainly composed of drugs to promote blood circulation and remove blood stasis.The main symptoms of lung menstrual blood heat syndrome are red spots,red papules,pustules and acne,which can be accompanied by skin lesions,itching,burning,dry mouth,thirst,yellow urine and red pharynx.The core prescription mainly consists of clearing heat and cooling blood,clearing lung menstrual blood heat drugs.The main syndromes of Chong-Ren disregulation syndrome are red papules,dark red papules,acne,pustules,obvious facial dullness,rough skin,which is clinically more common in adolescent and perimenopausal women,easy to aggravate before menstruation and menstruation.The core prescription is mainly kidney tonifying,invigorating blood and regulating menstruation drugs.The main syndromes of liver depression and qi stagnation are red papules,acne,pustules,nodules,dark complexion and other symptoms,including impatience,anxiety and poor sleep.Patients with high pressure,easy to stay up late,irregular work and rest.The core prescription is mainly composed of drugs for soothing liver and regulating qi.The main syndromes of deficiency of middle Yang are light red papules,red papules,acne,pustules,visible fear of cold,warm,poor tolerance,loose stool.The core prescription mainly consists of warm-tonifying Zhongyang,invigorating spleen and invigorating qi.ConclusionAccording to the complex network data mining,summarize Chen Tongyun’s core ideas and drug experience in the identification and treatment of acne,which is depend on the theroy of ’spleen rising and stomach descenging’:spleen and stomach dysfunction caused acne.The treatment is based on spleen and stomach and takes other treatments into consideration.①Pay attention to the normal rise and fall of spleen and stomach function:By clearing heat and dampness,invigorating spleen and dehumidifying,aromatizing dampness,warming and replenishing middle Yang to restore spleen and stomach function.②Pay attention to the influence of liver qi on the function of spleen and stomach:By regulating qi through the liver,invigorating the spleen and soothing the liver,clearing the liver and expelling fire and other treatment methods to dredge liver qi,help the spleen rise Yang,while strengthening the spleen and stomach,so that the spleen rise and stomach down orderly operation.③Pay attention to the lung,kidney,Chong-Ren meridian on the spleen and stomach lifting function:By clearing lung heat,tonifying liver and kidney,activating blood and regulating menstrual cycle to reinforce deficiency and reduce accumulation,so that the hub of Qi can be restored.④Pay attention to eliminating disease qi and protecting the spleen and stomach:Long course of disease,Qi blood body fluid impassability,It is easy to produce pathological products,leading to blockage of meridians,blockage of meridians,and spleen rise and stomach fall disorder,thus forming a two-way vicious cycle to aggravate the disease.By using the treatment methods of promoting blood circulation and removing blood stasis,drying dampness and reducing phlegm to clear the road.⑤Improve symptoms and treat both body and mind:The patients’ subjective discomfort symptoms should be treated,the patients should be warned of the matters to be paid attention to in the treatment of acne,and the patients with psychological burden caused by the loss of beauty should be psychologically relieved,and the body and mind should be treated together. |