| Objective: In this study,by observing the clinical efficacy of the Qingre Lishi Decoction combined with metronidazole in the treatment of reatment of dampness-heat trichomoniasis vaginitis and the changes of laboratory indexes of vaginal secretions,the possible mechanism of action was explored,in order to provide theoretical and scientific basis for the treatment of trichomonal vaginitis with Qingre Lishi Decoction.Methods:A total of 78 patients with damp-heat-infused TV who met the inclusion and exclusion criteria in the Department of Obstetrics and Gynecology of Gansu Provincial Hospital of Traditional Chinese Medicine from December,2021 to December,2022 were randomly divided into two groups,with 39 cases in each group.The control group was given metronidazole tablets 0.4g each time,twice a day.On the basis of the control group,the observation group was given Qingre Lishi decoction orally,1 dose a day,once in the morning and evening,half an hour after meals.Both groups were treated for 7 days.TCM syndrome score,vaginal lactobacillus,cleanliness,p H value and trichomonas results before and after treatment were observed and recorded in the two groups.After 3 months of follow-up after treatment,recurrence was recorded.Collect and sort the data,analyze and evaluate the curative effect.Result:1.The comparison of age,vaginal cleanliness,Lactobacillus quantification,p H value,total TCM evidence score and each individual score between the two groups before treatment at baseline showed no statistical difference(P>0.05)and were comparable.2.The intra-group comparison of vaginal cleanliness,Lactobacillus and p H between the two groups before and after treatment showed statistically significant differences(P<0.05).The inter-group comparison of vaginal cleanliness,Lactobacillus quantification,p H and trichomonas conversion between the two groups after treatment showed that there were no statistical difference in the improvement of p H and trichomonas conversion between the two groups(P>0.05).There were statistical difference in the improvement of vaginal cleanliness and the number of lactobacillus between the two groups(P<0.05),indicating that the observation group was more effective in improving vaginal cleanliness and increasing the number of lactobacillus.3.Compared the efficacy of TCM syndromes,the total effective rates of TCM syndromes in the observation group and the control group were 94.29% and 82.86%,respectively,with statistically significant difference(P<0.05),indicating that the efficacy of TCM syndromes in the observation group was better.The scores of each single item of TCM syndromes before and after treatment in the two groups were compared within the group,and it was found that the two schemes had the effect of reducing the TCM symptoms(P<0.05).There was no significant difference between the two groups in the improvement of smell,itching and burning degree,small abdominal pain,short red urine(P>0.05),but there was significant difference in the improvement of the amount of band,color quality,fatigue,bitter mouth,chest tightness and dull symptoms(P<0.05).The results showed that the observation group was better than the control group in the improvement of the volume and color quality of the band,drowsiness,fatigue,bitter and greasy mouth,chest tightness and dull symptoms,and the two groups had similar effects in other aspects.4.Compared the clinical efficacy of TV,the clinical efficacy of TV in the observation group was 91.42%,and that in the control group was 85.71%,the difference was statistically significant(P<0.05),indicating that the clinical efficacy of TV in the observation group was better than that in the control group.5.The comparison of recurrence rate,after the treatment,the effective patients in the two groups were followed up for 3 months,and the recurrence rate was counted and compared.The recurrence rate of the observation group was 12.12%,and that of the control group was 33.33%,with statistically significant difference(P<0.05),indicating that the observation group had more advantages in reducing the recurrence rate.Conclusion:1.Qingre Lishi Decoction combined with metronidazole is significantly more effective than the metronidazole alone group in treating patients with Chinese medicine symptoms of TV of the damp-heat type,and is significantly more effective in improving the symptoms of the amount and colour of the band,drowsiness and weakness,bitterness and greasiness of the mouth,chest tightness and dullness.2.The clinical efficacy of Qingre Lishi Decoction combined with metronidazole in the treatment of damp-heat-infused TV is better than that of the metronidazole alone group,and it can significantly reduce the recurrence rate of TV.3.Qingre Lishi Decoction combined with metronidazole has the effect of improving the vaginal micro-ecological index of the patients,and is better than the control group in improving vaginal cleanliness and increasing the number of lactobacillus. |
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