Associationof Red Cell Distribution Width With The Severity Of Stable Coronary Artery Disease In Postmenopausal Women

Objective: The aim of the study was to examine whether RDW was a predictor for the severity of stable coronary artery disease(SCAD)in postmenopausal women.Methods: A total of 700 postmenopausal women with first angina-like chest pain were enrolled and divided into two groups according to the results of coronary angiography: CAD group(n = 314)and non-CAD group(n = 386).Patients with CAD were further classified into three groups based on the tertile of Gensini scores(GS).The baseline demographic,major risk factors of CAD and RDW among the groups were analyzed.The association between RDW levels and severity of CAD were evaluated,and the predictive value of RDW for CAD was examined.Results: RDW levels were significantly higher in the patients with CAD compared to non-CAD(13.26±1.08 vs 12.57±0.45,P<0.001).The multivariate logistic regression analysis suggested that RDW was an independent predictor of CAD(OR=4.61,95% CI: 4.40-4.84,P<0.001).The receiver-operating characteristic(ROC)analysis indicated the area under the curve of RDW was 0.73,with an optimal cutoff value of 12.95%(sensitivity : 57.9%,specificity : 78.6%).Furthermore,there was a positive correlation between RDW and the GS(r = 0.37,P < 0.001).The multivariate logistic regression analysis demonstrated RDW was an independent predictor for GS(OR=2.60,95%CI: 2.47-2.73,P<0.001).Conclusion: RDW is an independent predictor for the severity of SCAD in postmenopausal women.