Correlation Analysis Between Monocyte To High-density Lipoprotein Cholesterol Ratio And The Severity Of Coronary Artery Disease In Postmenopausal Women

Objective: To investigate the correlation between monocyte to high-density lipoprotein cholesterol ratio(MHR)and the incidence and severity of coronary artery disease in postmenopausal women.Methods: This study retrospectively included 362 postmenopausal women diagnosed with coronary heart disease by coronary angiography in the department of cardiology,the first hospital of Lanzhou University from September 2018 to September 2019 as the coronary heart disease group,and evaluated the severity of coronary artery disease by using Gensini score.Meanwhile,199 postmenopausal women with normal coronary angiography results are used as the control group,and recorded the basic data of all cases Data,medical history and various examination indexes were compared with baseline data of the two groups.The binary Logistic regression analysis was performed and the ROC curve of the subjects was drawn.Secondly,the coronary heart disease group was divided into three subgroups: light,medium and heavy according to the Gensini score.The differences of baseline data between the groups were compared,and the multiple ordered Logistic regression analysis and Pearson correlation analysis were performed.Results: 1.The age,diabetes,hypertension,white blood cell count(WBC),neutrophil count(NEUT),monocyte count(MONO),aspartate aminotransferase(AST),gamma-glutamyl transpeptidase(GGT),glucose(Glu),lactate dehydrogenase(LDH),5-hydroxybutyrate dehydrogenase(?-HBDH),fibrinogen(FIB),and MHR of CHD group were higher than the control group,the difference was statistically significant(P < 0.05).The red blood cell count(RBC),hemoglobin(Hb),high density lipoprotein cholesterol(HDL-C),albumin(ALB)and left ventricular ejection fraction(LVEF)were significantly lower than those of the control group(P < 0.05);Binary logistic analysis showed that age,diabetes,hypertension,NEUT,MHR,Glu,LDH and FIB were risk factors of coronary heart disease in postmenopausal women,RBC and LVEF were protective factors.2.ROC curve analysis showed that the area under the curve of MHR was 0.676(95%CI: 0.631-0.721).When the critical value of MHR was 0.26,the diagnostic efficiency was the highest,the sensitivity was 70.7%,and the specificity was 59.8%;3.There were significant differences in age,WBC,NEUT,MONO,HDL-C,LDLC,AST,ALB,LDH,?-HBDH,FIB,LVEF and MHR among the three groups were statistically significant(P <0.05).The age,WBC,NEYT,MONO,AST,LDH,?-HBDH,FIB and MHR of moderate group were higher than those of mild group,HDLC,ALB were lower than mild group,LVEF were lower than mild and moderate group;age,WBC,NEUT,MONO,AST,LDH,?-HBDH,FIB,MHR of the moderate group were higher than those of mild group,while HDL-C,ALB,and LVEF were lower than the mild group,with statistically significant differences(P <0.05);multiple Logistic regression analysis indicated that MHR and LDL-C were risk factors for the severity of coronary artery lesions in postmenopausal women,and LVEF was the protective factor.4.The correlation analysis between Gensini score and multiple factors showed that Gensini score was positively correlated with WBC(r=0.196),NEUT(r=0.202),MONO(r=0.189),MHR(r=0.226),TC(r=0.140),LDL-C(r=0.164)and UA(r=0.107)(P<0.05),and negatively correlated with HDL-C(r=-0.107)and LVEF(r=-0.302)(P<0.05).5.Pearson correlation analysis showed that MHR was positively correlated with Gensini score(r = 0.266,P < 0.001).Conclusions: 1.MHR is related to postmenopausal women with coronary heart disease,which can be used as a reference indicator to predict the occurrence of coronary heart disease in postmenopausal women;2.MHR has a positive correlation with the severity of coronary artery disease in postmenopausal women,which has a certain reference value for predicting the severity of coronary artery disease.