| ObjectiveTo observe the effect of Dihong Formula on TCM syndrome score,blood glucose,serum IGF-1,serum VEGF,serum Cys-C and e GFR in elderly patients with type 2 diabetic nephropathy of yin deficiency and blood stasis type,and to explore the efficacy,safety and mechanism of Dihong Formula in the treatment of elderly patients with type 2 diabetic nephropathy.MethodFrom March 2022 to March 2023,76 elderly patients who met the diagnostic criteria of type 2 diabetic kidney disease and the syndrome of Yin deficiency and blood stasis were randomly divided into the experimental group and the control group at the Department of Geriatrics,the Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine,with 38 cases in each group.The control group was treated with western medicine alone,and the experimental group was treated with Dihong Formula orally on the basis of the treatment in the control group for 4 weeks.Observe the changes of TCM syndrome score,FBG,2h-PG,GA,IGF-1,VEGF,Cys-C,urea nitrogen,creatinine,uric acid,e GFR and UACR levels before and after treatment in the two groups.A total of 20 healthy subjects were set up to observe the differences of the above indexes between them and the diabetic nephropathy group(experimental group and control group)before treatment,and the experimental results were statistically analyzed.Result1.Comparison between the diabetic renal disease group and the healthy group: there was no statistical difference in gender,age,urea nitrogen and creatinine between the two groups(P > 0.05),with comparability;there were statistical differences in BMI,IGF-1,VEGF,Cys-C,FBG,2h-PG,GA,uric acid and e GFR between the two groups(P < 0.05).2.Comparison of data between the experimental group and the control group before treatment: there was no statistical difference in gender,BMI,age,course of disease,health status,distribution of combined diseases,TCM syndrome score before treatment,IGF-1,VEGF,Cys-C,glycosylated hemoglobin,FBG,2h-PG,GA,UACR,urea nitrogen,creatinine,uric acid,and e GFR between the two groups,with comparability(P > 0.05).3.Comparison of curative effect between the experimental group and the control group:After treatment,the TCM syndrome scores of both groups were significantly lower than those before treatment(P < 0.01);the TCM syndrome score difference of the experimental group was significantly higher than that of the control group(P < 0.01).The total effective rate of TCM syndrome score was 97.37% in experimental test group and 71.05% in the control group,and the difference was statistically significant(P < 0.01).The overall efficacy was 31.58% in the experimental group and 5.26% in the control group,and the difference was statistically significant(P < 0.05).4.Comparison of blood glucose between the experimental group and the control group:After treatment,the FBG,2h-PG and GA levels in the experimental group were significantly lower than those before treatment(P < 0.01);the FBG,2h-PG and GA levels in the control group were not significantly different from those before treatment(P > 0.05);the difference of FBG,2h-PG and GA in the experimental group was higher than that in the control group,and the difference was statistically significant(P < 0.05).5.Comparison of IGF-1,VEGF and Cys-C between the experimental group and the control group: After treatment,the serum IGF-1,VEGF and Cys-C in the two groups were significantly lower than those before treatment(P < 0.01);the difference of IGF-1,VEGF and Cys-C in the experimental group was higher than that in the control group,and the difference was statistically significant(P < 0.01).6.Comparison of renal function between the experimental group and the control group:After treatment,there was no significant difference in urea nitrogen,creatinine,uric acid and e GFR between the two groups compared with those before treatment(P > 0.05).There was significant difference in UACR between the two groups compared with those before treatment(P < 0.05).The difference in urea nitrogen,creatinine,uric acid,e GFR and UACR between the experimental group and the control group was slightly greater than that in the control group,but the difference was not statistically significant(P > 0.05).7.Comparison of safety indexes: AST,ALT,PT,APTT,K,Na and ECG showed no abnormality before and after treatment in both groups,and there was no difference between the two groups.No adverse reaction was observed during the treatment intervention,indicating good safety.Conclusion1.Dihong Formula can improve the TCM syndrome of elderly patients with type 2diabetic kidney disease of yin deficiency and blood stasis type,and Dihong Formula combined with western medicine is superior to western medicine alone in the treatment of TCM syndrome of elderly patients with type 2 diabetic kidney disease of yin deficiency and blood stasis type.2.Dihong Formula can reduce the serum FBG,2h-PG,and GA levels in elderly patients with type 2 diabetic kidney disease.3.Dihong Formula can reduce the serum levels of IGF-1,VEGF and Cys-C in elderly patients with type 2 diabetic kidney disease of yin deficiency and blood stasis type.4.Dihong Formula has good clinical safety in the treatment of elderly patients with type2 diabetic kidney disease of yin deficiency and blood stasis type. |
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