| ObjectiveTo explore the efficacy and partial mechanism of Dihong Formula,we observed the effect of Dihong Formula on TCM syndrome score,blood glucose,blood lipid,Lp-PLA2,CTRP3 and Hcy in elderly patients with type 2 diabetes and atherosclerosis of yin deficiency and blood stasis type.MethodsFrom March 2022 to February 2023,72 elderly patients who met the diagnostic criteria of type2 diabetic atherosclerosis and the syndrome of Yin deficiency and blood stasis type were randomly divided into the experimental group and the control group,with 36 cases in each group.The control group was treated with Western medicine alone,and the experimental groups were given Dihong Formula orally on the basis of the treatment of the control group.The course of treatment was 4weeks.The changes of TCM syndrome score,FBG,2h-PG,GA,TC,TG,LDL-C,HDL-C,Lp-PLA2,CTRP3,Hcy and safety indexes before and after treatment in two groups were observed.Twenty healthy subjects were set up to observe the differences in the above indicators between them and diabetic atherosclerosis group(experimental group and control group)before treatment,and the test results were statistically analyzed.Results1.Comparison between diabetic atherosclerosis group and healthy group: There was no statistical differences in gender and age between the two groups(P > 0.05);The CTRP3 and HDL-C levels in two groups were significantly lower than those in the healthy group(P < 0.01),the serum Lp-PLA2,Hcy,FBG,2h-PG,GA and TG levels were significantly higher than those in the healthy group(P < 0.01),and the BMI and TC levels were higher than those in the healthy group(P< 0.05).2.Compared with the control group before treatment: There was no significant difference in age,gender,course of disease,BMI,TCM syndrome score,Lp-PLA2,CTRP3,Hcy,Hb A1 c,FBG,2h-PG,GA,carotid atherosclerosis score,lower limb arteriosclerosis score,TC,TG,LDL-C and HDL-C between the two groups(P > 0.05).It is comparable.3.Efficacy comparison: After treatment,the TCM syndrome scores of the two groups were significantly lower than those before treatment(P < 0.01);The decreasing range of TCM syndrome scores of the experimental group was significantly higher than that of the control group(P < 0.01),and the difference of TCM syndrome efficacy between the two groups was statistically significant(P < 0.01).The overall effective rate was 50.00% in the experimental group,and 11.11% in the control group,the difference was statistically significant(P < 0.01).4.Blood glucose comparison: After treatment,FBG,2h-PG and GA in the experimental group decreased compared with those before treatment(P < 0.01);GA in the experimental group decreased more than that in the control group(P < 0.05),with statistical differences.5.Comparison of Lp-PLA2,CTRP3 and Hcy between two groups: After treatment,the serum levels of Lp-PLA2 and Hcy in two groups were significantly lower than those before treatment(P <0.01),the decrease of Lp-PLA2 in the experimental group was significantly higher than that in the control group(P < 0.01),and the decrease of Hcy in the experimental group was higher than that in the control group(P < 0.05);After treatment,the CTRP3 was significantly increased in both groups compared with before treatment(P < 0.01),and the increase of CTRP3 in the experimental group was significantly higher than that in the control group(P < 0.01).6.Comparison of blood lipid: After treatment,TC in the experimental group was significantly different from that before treatment(P < 0.01),LDL-C in the experimental group was lower than that before treatment,and the difference was statistically significant(P < 0.05).There was no significant difference in the change range of TC,TG,LDL-C and HDL-C between the experimental group and the control group(P > 0.05).7.Comparison of safety indexes: Before and after treatment,liver and kidney function,coagulation,electrolytes,hematuria and fecal routine and electrocardiogram showed no abnormalities in the two groups,and there was no difference between the two groups.No adverse reactions were observed during the treatment intervention.Conclusions1.Dihong Formula can improve the TCM syndrome score of elderly patients with type 2 diabetes and atherosclerosis of yin deficiency and blood stasis type,and the efficacy of Dihong Formula combined with western medicine in treating elderly patients with type 2diabetes and atherosclerosis of yin deficiency and blood stasis type is better than that of western medicine alone.2.Dihong Formula can improve glucose and lipid metabolism by regulating the levels of FBG,GA,TG,LDL-C in elderly patients with type 2 diabetes and atherosclerosis of yin deficiency and blood stasis type;3.Dihong Formula can increase the level of CTRP3 and reduce the levels of Lp-PLA2 and Hcy in elderly patients with type 2 diabetes and atherosclerosis of yin deficiency and bloodstasis type.4.Dihong Formula is safe in the treatment of elderly patients with type 2 diabetes and atherosclerosis of yin deficiency and blood stasis type. |
