| Objective:To observe the changes of serum hypersensitivity C-reactive protein(hs-CRP),cystatin C(Cys C)and related laboratory indexes after Tangshenkang granule intervened in diabetic kidney disease(DKD)patients with qi-yin deficiency and blood stasis syndrome.To evaluate the changes of clinical syndrome of traditional Chinese medicine(TCM)and to explore the therapeutic effect and possible mechanism of Tangshenkang granule on DKD patients with qi-yin deficiency and blood stasis syndrome.Method:70 patients with DKD syndrome of deficiency of qi and yin and blood stasis were randomly divided into Tangshenkang group(n = 35)and control group(n = 35)who met the inclusion criteria from March 2018 to December 2018 in the Department of Nephrology and Endocrinology in our hospital.There were 20 cases in the normal group.The patients in the Tangshenkang group and the control group were treated with basic treatment of western medicine(lowering blood pressure,regulating blood sugar and blood lipid,etc.),The patients in the Tangshenkang group were treated with Tangshenkang granules,one bag for each time,three times a day.The course of treatment in both groups was 8 weeks.The 24 hour urinary protein quantity(24hUPr)and urinary microalbumin / urinary creatinine ratio(UACR)were compared before and after treatment.The changes of renal function,blood glucose and serum hs-CRP,Cys C were observed before and after treatment,and the curative effect was evaluated and analyzed statistically.Results: the therapeutic effects of TCM syndromes and clinical diseases in the Tangshenkang group were significantly better than those in the control group(P < 0.05),and the scores of TCM syndromes in the Tangshenkang group decreased significantly after treatment for 4 weeks and 8 weeks(P < 0.01),compared with those of the control group(P < 0.05).In the control group,there was no significant difference after 4 weeks of treatment(P > 0.05),but there was a significant decrease after 8 weeks of treatment(P < 0.01).The UACR,24 hUPr of Tangshenkang group was significantly higher than that of control group at the same time(P < 0 05 or P < 0 01),and compared with that before treatment,the UACR,24 hUPr of Tangshenkang group was significantly higher than that of pre treatment group at 4 weeks and 8 weeks after treatment(P < 0 05 or P < 0 01).(P <0.05 or P <0.01).There was no significant difference between the control group and the control group after 4 weeks(P> 0.05),and there was a significant decrease after 8 weeks(P <0.05).Compared with the control group in the same period,the UACR and 24 hUPr of the group showed no difference after 4 weeks of treatment(P> 0.05),and decreased significantly after 8 weeks(P <0.05).There was no significant improvement in FPG,2hPG,HbA1 c,BUN,Scr and eGFR in the two groups(P> 0.05),and the serum hs-CRP and Cys C in the first two groups.C level was significantly higher in the normal group than that in the normal group(P < 0.01).After treatment,the level of serum hs-CRP,Cys C in Tangshenkang group was significantly lower than that in control group(P < 0.05),and the improvement of both indexes in Tangshenkang group was significantly better than that in control group(P < 0.05).Conclusion:Tangshenkang granule has significant therapeutic effect on reducing urinary protein and improving clinical symptoms in DKD patients with qi-yin deficiency and blood stasis syndrome.The serum hs-CRP,Cys C level in patients with DKD is significantly higher than that in healthy people.Tangshenkang granule can significantly reduce the level of serum hs-CRP,Cys C,which may be one of the mechanisms of Tangshenkang granule in treating DKD. |
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