| ObjectiveTo observe the effects of Dihong Formula on TCM syndrome score,serum SDF-1,serum MCP-1,serum NO,blood glucose and blood lipid of elderly Type 2 Diabetes patients with Yin Deficiency and Blood Stasis,and to explore the efficacy,safety and mechanism of Dihong Formula in the treatment of elderly Type 2 Diabetes.MethodsFrom February 2021 to January 2022,90 patients who met the diagnostic criteria of geriatrics type 2 diabetes and the criteria of Yin deficiency and blood stasis syndrome were collected in the Geriatrics Department of the Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine.They were randomly divided into experimental group and control group,with 45 cases in each group.The control group was given pure Western medicine treatment,and the experimental group was given Dihong Formula oral treatment on the basis of the treatment of the control group.The course of treatment was 14 days.The changes of Hb A1 c before treatment,TCM syndrome score,SDF-1,MCP-1,NO,FBG,2H-PG,GA,TC,TG,LDL-C and HDL-C before and after treatment in 2 groups were observed.Twenty healthy patients in the control group were set up,and the differences of above indexes between them and the diabetic group(experimental group and control group)were observed before treatment,and the experimental results were statistically analyzed.Results1.Comparison between diabetic patients and healthy control group: there were no statistically significant differences in gender,age and BMI between diabetic patients and healthy control group(P>0.05),indicating comparability;The levels of SERUM SDF-1 and NO in diabetic patients were significantly lower than those in healthy control group(P< 0.01),and the levels of serum MCP-1,FBG,2H-PG and GA were significantly higher than those in healthy control group(P< 0.01).The levels of TC,TG and LDL-C were statistically different from those in healthy control group(P< 0.05).The level of HDL-C was lower than that of healthy control group(P< 0.01).2.Comparison of data between the two groups: there were no significant differences in age,gender,course of disease and BMI between the two groups(P>0.05),indicating comparability.Comparison of indicators between the two groups: there were NO significant differences in TCM syndrome score,SDF-1,MCP-1,NO,blood glucose and blood lipids between the two groups before treatment(P>0.05),indicating comparability.3.Comparison of efficacy: After treatment,TCM syndrome scores of the two groups were significantly decreased(P<0.01),and the decrease range of experimental group(difference before and after treatment)was greater than that of control group(P<0.05);The effective rates of TCM syndromes in the two groups were 95.56% and 58.14%,respectively,and the difference was statistically significant(P<0.01).The overall effective rate of the two groups was 44.44% and 27.91%,respectively,with no statistical significance(P>0.05).4.Blood glucose comparison: After treatment,the levels of FBG,2H-PG and GA in 2groups decreased compared with before treatment(P<0.01);The decrease of GA in experimental group(difference before and after treatment)was higher than that in control group(P< 0.05).5.Comparison of SDF-1,NO and MCP-1 between 2 groups: After treatment,the levels of serum SDF-1 and NO in 2 groups were significantly increased compared with before treatment(P<0.01),and the increase of SDF-1 and NO in experimental group(difference before and after treatment)was greater than that in control group(P<0.05).The serum MCP-1level in experimental group was decreased compared with before treatment(P<0.01),while that in control group was not significantly changed(P>0.05).The decrease of MCP-1 in experimental group(difference before and after treatment)was greater than that in control group(P<0.05).6.Comparison of blood lipids: After treatment,the levels of TC,TG and LDL-C in experimental group and control group decreased compared with before treatment(P<0.05),the level of HDL-C in experimental group increased compared with before treatment(P<0.01),and the increase in experimental group(difference before and after treatment)was greater than that in control group(P<0.05).7.Comparison of safety indicators: Before and after treatment,there were no abnormalities in glutamic-oxalacetic transaminase,glutamic-pyruvic transaminase,urea nitrogen,creatinine,thrombin time,activated partial thrombin time,blood potassium,blood sodium and electrocardiogram between the two groups.There were no adverse reactions during treatment intervention,indicating good safety.Conclusion1.Dihong Formula can improve the TCM syndromes of Yin Deficiency and Blood Stasis Type 2 Diabetes patients.The TCM syndromes and overall efficacy of Dihong Formula combined with Western medicine in the treatment of Yin Deficiency and Blood Stasis Type 2Diabetes patients are superior to western medicine alone.2.Dihong Formula may improve glucose and lipid metabolism in Type 2 Diabetes patients with Yin Deficiency and Blood Stasis by regulating the levels of GA,TC,TG,LDL-C and HDL-C.3.Dihong Formula may reduce the level of MCP-1 and increase the level of SDF-1 and NO in Type 2 Diabetes patients with Yin Deficiency and Blood Stasis,so as to improve vascular inflammation and injury.4.Dihong Formula has good safety in the treatment of Yin Deficiency and Blood Stasis Type 2 Diabetes. |
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