The Association Of Obstructive Sleep Apnea In Children With Allergic Diseases And Allergen Sensitization Summary

PurposeTo analyze the correlation of obstructive sleep apnea(obstructive sleep apnea,OSA)with allergic diseases and allergen sensitization,explore the effects of allergic diseases and allergen sensitization on OSA in children,and provide clinical research basis for the clinical diagnosis and treatment of OSA in children.MethodsUsing a retrospective study method,selected the period from October 2021 to 2021 August 2022 in the department of medical treatment,111 children with OSA(polysomnography,PSG)according to the diagnosis and treatment guidelines(2020).According to the presence of allergic disease,obstructive apnea,hypopnea index(obstructive a pnea hypopnea index,OAHI)and low ventilation index for group;Collect and record the clinical data(including age,sex,height,weight,current medical history,past history,etc.)and the relevant test results(eosinophil percentage,allergen test results,PSG related indicators,etc.),The analysis and comparison of relevant data between each group respectively;PSG parameters and allergy test indicators;The L ogistic regression analysis of indicators for comparison between groups,To further clarify the correlation between OSA and the influencing factors of allergic diseases.At the same time,the allergen test results of 111 OSA children were integrated and summarized to clarify the distribution of allergen sensitization status in this group.Results1.General situation:Among the 111 children in this study,67(60.4%)were male and 44(39.6%)were female,with a median age of 4.50 years.Normal height,5 short,1 short,13 high,11 high;97 normal BMI,0 thin,2 overweight and 12 obese.2.Distribution of allergens:Among 111 children with OSA,87(78.38%)were positive for allergens and 24(21.62%)were negative for allergens.OSA,the inhalation allergen of the child,the top three were dust mite combination,house dust,and cross,and the top three feeding allergens were egg,milk and wheat.3.Comparison between the group without allergic disease and those with allergic disease:66 of 111 children(59.5%),45(40.5%)in the no-allergic disease group,There was no significant difference between gender,age,BMI,light sleep time ratio,deep sleep time ratio,and REM sleep time ratio between the two groups(P 0.05);OAHI,low ventilation index and apnea index were higher than the group without allergic disease,The imum oxygen saturation was lower than in the group without allergic disease,And the difference between the two groups was statistically significant(P<0.005).4.Comparison of allergy-related indicators in 5 groups of children grouped with OAHI values:4.1 There were no significant differences in gender,aye,total IgE abnormality rate,positive rate of allergen detection and percentage of eosinophil in the 5 groups(P>0.05);4.2 The difference of allergic diseases in 5 groups was statistically significant(P<0.05).5.Comparison of allergy-related indicators in group 2 children grouped in hypoventilation,index:5.1 There was no significant statistical difference in sex,age,and percentage of eosinophils between the 2 groups(P>0.05);5.2 Significant differences in total IgE abnormalities,allergen detection and allergic disease prevalence between the 2 groups(P=0.029、0.046、0.023).6.Correlation between PSG parameters and eosinophil indicators:OAHI,apnea index,hypoventilation index,low sleep duration,deep sleep duration,REM sleep duration and minimum oxygen saturation and percentage of eosinophils(P>0.05).7.Allergy related indicators,the regression analysis of hypoventilation index level:gender,age,BMI,eosinophil percentage on hypoventilation index no statistical difference(P>0.05),the influence of allergic disease on hypoventilation index has statistical difference(P<0.05),allergic disease is a risk factor of higher hypoventilation index,suggesting that allergic disease may increase hypoventilation index.conclusion:1.In the positive rate of allergen detection in OSA children,the top three inhalation group were dust mite combination(house dust mite/dust mite),house dust and C.rakoxus,and the top three allergens in food intake group were egg,milk and wheat.2.The presence of allergic diseases will aggravate the severity of sleep and respiratory disorders in OSA children,which suggests that we should give early intervention and treatment to OSA children combined with allergic diseases,so as to strengthen the prevention and treatment effect of OSA,avoid the aggravation of OSA,and reduce the occurrence of OSA complications.3.The presence of allergic diseases has an impact on the severity of childhood OSA and has some predictive value on the impact of OSA severity.