Analysis Of TCM Syndromes And Medication Rules Of Post-stroke Insomnia Based On Data Mining

Target: Based on data mining technology,the types of post-stroke insomnia and traditional Chinese medicine formulas in literature journals were analyzed,the characteristics of their symptoms,the high-frequency use of traditional Chinese medicines,drug combinations and the composition rules therein were excavated,the pathological characteristics and medication rules of post-stroke insomnia were explored,and the principles of prescription and medication used by modern doctors for the treatment of post-stroke insomnia were discussed,in order to provide a reference basis for clinical differentiation and rational drug use.Methods: The computer retrieve the literature and periodicals of CNKI,Wan Fang,VIP and Pub Med databases,set the search time period from January2000 to November 2022,selected qualified literature journals with inclusion criteria and exclusion criteria,and then used Excel 2016 to enter data and normalize the data,so as to establish a database of common symptoms of post-stroke insomnia and traditional Chinese medicine formulas based on literature journals.The statistical software Excel 2016,SPSS Statistics 26.0 and IBM SPSS Modeler18.0 were available to analyze the distribution regularity of the traditional Chinese medicine syndrome type,cluster analysis,and the drug use frequency,association rules and complex network analysis and cluster analysis for the use of traditional Chinese medicine.Results:1.Study on the characteristics of post-stroke insomnia:(1)A total of 79 articles were included in this study,89 evidence types were recorded,covering 27 TCM certificate types,involving 6434 cases.(2)the disease location covers the mind(2196 cases,38.7%),liver(1355 cases,23.88%),kidney(848 cases,14.94%),heart(493 cases,8.69%),spleen(425cases,7.49%),meridians(280 cases,4.93%),and half surface(78 cases,1.37%).(3)There are a total of 22 pathological syndrome combinations,including 6 single pathological syndromes,12 two-pathological combination and 4 three-pathological combination syndromes.Splitting the combination of two or more pathogenic factors found that a single pathogenic symptom could be attributed to phlegm(2599 cases,22.31%),fire/heat(2441 cases,20.95%),blood stasis(2135 cases,18.33%),deficiency(3226 cases,27.69%),and Qi stagnation(711 cases,6.10%).The deficiency factors were mainly yin deficiency(1358 cases,11.66%)and qi deficiency(1234 cases,10.59%),and Qi stagnation was mainly manifested as liver depression and Qi stagnation,which is a characteristic pathological feature.(4)Cluster analysis can obtain 4 categories: C1: phlegm + fire/heat + mind +half surface and half li;C2: blood stasis + meridians;C3: Yin deficiency + liver+ kidney + Qi stagnation + yang hyperactivity + yang deficiency + moving wind;C4: Qi deficiency + heart + blood deficiency + spleen.2.Study on the law of traditional Chinese medicine for post-stroke insomnia:(1)A total of 144 articles and 152 prescriptions were included in the study,involving 145 flavors of traditional Chinese medicine.(2)A total of 35 flavors of Chinese medicine were used more than or equal to 20 times,including sour jujube kernel(84 times),poria(76 times),licorice(65 times),Chuanxiong(64times),angelica(59 times),etc.(3)The classification of the four qi of traditional Chinese medicines was mostly flat(565 times,32.36%)and warm(449 times,25.72%),accounting for 58.08%;Five flavors were common in sweet(934 times,34.04%),bitter(632 times,23.03%),and spicy(584 times,21.28%),accounting for 78.35%;The meridians were mainly attributed to the heart(956 times,19.07%)and liver(919 times,18.33%),accounting for 37.4%;The efficacy of drugs involved 19 kinds,including deficiency tonic drugs(432times,24.77%),tranquilizers(275 times,15.77%),antipyretic drugs(196 times,11.24%),and blood stasis revitalizing drugs(195 times,11.18%).(4)The analytical results of association rules make known that there were 20 drug pairs,including Chuanxiong,red peony,poria,zhuru,tangerine peel,huanglian,citrus fruit,peach kernel,banxia,keel,oyster,astragalus,angelica,safflower,sour jujube renyuanzhi,a total of 16 flavors of traditional Chinese medicine.(5)Phylogenetic clustering can be classified into five categories: C1: sour jujube kernel,angelica,yuanzhi,shouwuteng,astragalus,baiju,Fushen,acacia peel,codonopsis;C2: Poria,Banxia,Coptis,Tangerine Peel,Citrus aurantium,Licorice,Zhuru;C3: Red peony,white peony,saihu,licorice,raw ground yellow,cooked ground yellow,Chuanxiong,peach kernel,safflower,ox knee;C4: Skullcap,oyster,keel,date,ginger;C5: Calamus,salvia,tulip,earth dragon.Conclusion:1.The syndrome elements of disease location of patients with post-stroke insomnia are mainly for the heart,liver,kidney,heart,and the pathogenic factors can be attributed to five categories: phlegm,fire / heat,blood stasis,deficiency and qi stagnation,of which most of the deficiency factors are yin deficiency,and qi stagnation is mainly manifested as liver depression and qi stagnation,which is a characteristic pathological feature,suggesting that patients with post-stroke insomnia are more likely to have symptoms of liver depression and qi stagnation than the general population,and clinically attention should be paid to grasping the treatment principle of soothing the liver and regulating qi.2.Post-stroke insomnia often occurs in the form of two or more factors,clustering results show that the main symptom of post-stroke insomnia included phlegm fire disturbing,blood stasis internal obstruction,heart and spleen deficiency,liver and kidney deficiency.Symptomatic features correlate with the acute and convalescent course of stroke.During diagnosis and treatment,careful differentiation should be carried out to grasp the etiology and pathogenesis and its dynamic characteristics.3.Drugs such as sour jujube kernel,shouwuten,keel,oyster,banxia,poria and other drugs are not only high-frequency drugs for the treatment of insomnia after stroke,but also drugs involved in association rules and cluster analysis,indicating that it is the core drug for the treatment of insomnia after stroke,reflecting the treatment principles of calming the nerves,clearing heat and phlegm,activating blood and removing stasis.The principle of contemporary doctors in treating insomnia after stroke is to replenish deficiency and dispel evil,which is to regulate qi and blood,clear heat and phlegm,activate blood and remove stasis,and supplement it with tranquilizing drugs to treat the symptoms.4.After stroke,the patient’s qi and blood are weak,but the stroke patient has heavy phlegm and stasis,so it is not necessary to blindly replenish the deficiency,but should pay attention to the principle of dispelling evil,and clear heat,dissolve phlegm,activate blood and remove stasis on the basis of reasonable differentiation,so as not to help evil and hurt the right.