Clinical Observation Of Chaihu Hehuan Jieyu Decoction In The Treatment Of Insomnia Of "Gan Huo Rao Xin" Related To Generalized Anxiety Disorder

Objective: Chaihu Hehuan Jieyu Decoction was used to treat the insomnia of “gan huo rao xin” related to generalized anxiety disorder.We observed the clinical effect of this prescription,in order to provide theoretical basis and practical experience in the application of this prescription in insomnia.Methods: Sixty sleepless patients fulfilled the standard were collected and divided into control group(n=30)and treatment group(n=30).Patients of the control group were treated with alprazolam,while patients of the treatment group were treated with Chaihu Hehuan Jieyu Decoction on the basis of alprazolam(4 weeks).The Pittsburgh Sleep Index Number Table(PSQI),Hamilton Anxiety Scale(HAMA),and TCM syndrome points were observed and analyzed between two groups,in order to compare the changes and the differences before and after treatment.Statistical analysis were performed using SPSS26.0software.Results: Clinical efficacy of the insomnia: by comparison the PSQI scale between the two groups,the treatment group was effective at 93.33% and the control group was effective at 73.33%.The treatment group was better than the control group,and the difference were statistically significant(P < 0.01).Clinical efficacy of generalized anxiety disorder: by comparison the HAMA scale between the two groups,the treatment group was effective at 93.33% and the control group was effective at 66.67%.The treatment group was better than the control group,and the difference were statistically significant(P <0.01).Comparison of TCM syndrome efficacy: by comparison the TCM syndrome points between the two groups,the treatment group was effective at 96.67% and the control group was effective at 66.67%.The treatment group was better than the control group,and the difference were statistically significant(P < 0.01).Safety analysis: we speculated this prescription has well safety due to the fact that neither of the two groups had significant adverse reactions.Conclusion: Chaihu Hehuan Jieyu Decoction could effectively improve the sleep quality of patients with the insomnia of “gan huo rao xin” related to generalized anxiety disorder,correct their insomnia symptoms and relieve their anxiety state.The effect of this prescription was significant and there were no obvious side effects and adverse reactions.We considered that this prescription could be used in clinical practice.