Clinical Observation Of Jianpi Bushen Herbalpaste Combined With Navel Moxibustion In The Treatment Of Decreasing Ovarian Reservation

Objective: To study the clinical effect of Jianpi Bushen herbalpaste combined with umbilical moxibustion and Fenmotong,and Fenmotong used alone in the treatment of DOR patients with spleen-kidney yang deficiency.The efficacy evaluation was based on the patient’s serum hormone level,antral follicle numbers,menstrual status and Traditional Chinese medicine(TCM)syndromes as joint evaluation indicators,which provided a safe and effective solution for the combination of herbalpaste and umbilical moxibustion to improve ovarian reserve.Methods:The DOR patients who met the criteria were divided into an observation group and a control group by a random control method.A total of 28 patients in the observation group were treated with integrated traditional Chinese and western medicine,and a total of27 patients in the control group were treated with western medicine alone.Both groups started to take Fenmaton on the 3rd day of the menstrual cycle,1 tablet per day,first white tablets,then gray tablets,28 days as a course of treatment,a total of 3 courses of treatment;On the basis of the treatment of the control group,the observation group was treated with Jianpi Bushen herbalpaste combined with umbilical moxibustion.After 3 months of treatment,the improvement of ovarian function,menstruation,and TCM symptoms were compared between the observation group and the control group,and data analysis was used to draw conclusions.Results:1.Comparison of TCM syndromes:It consists of menstrual points and TCM syndrome points.(1)Within-group comparison: The menstrual color quality,menstrual cycle,menstrual volume,total menstrual score and total score of TCM syndromes in the two groups after treatment were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).(2)Comparison between groups: After statistical analysis,there was no significant difference in the menstrual scores and TCM syndrome scores between the two groups before treatment(P>0.05);and there were significant differences in the menstrual scores and TCM syndrome scores between the two groups after treatment(p<0.05).2.Comparison of ovarian function: mainly including serum follicle stimulating hormone(FSH)levels,luteinizing hormone(LH)levels,estradiol(E2)levels,anti-Müllerian hormone(AMH)levels and antral follicle number(AFC).(1)Within-group comparison: The FSH and LH of the two groups after treatment showed a downward trend compared with those before treatment,and the E2,AMH,and AFC of the two groups after treatment showed an upward trend compared with those before treatment,and the differences in serum hormone levels and AFC between the two groups were statistically significant academic significance(P<0.05).(2)Comparison between groups: The FSH levels,LH levels,E2 levels,and AMH levels before treatment in the two groups were not statistically significant compared with AFC(P>0.05),which were comparable.There were significant differences in FSH,LH,and AMH levels between the two groups after treatment compared with AFC(P<0.05).There was no statistically significant difference in E2 levels between the two groups after treatment,and the treatment effects of the two groups were roughly the same.3.Comparison of clinical comprehensive efficacy: Comparing the clinical comprehensive efficacy of the two groups after treatment,it was found that the total effective rate of the observation group was 89.31% higher than that of the control group,which was 74.07%,indicating that the clinical comprehensive efficacy of the observation group was better than that of the control group.After rank sum test analysis,the differences between the two groups were statistically significant(P<0.05).Conclusion:For DOR patients with spleen-kidney yang deficiency,the application of Jianpi Bushen herbalpaste and umbilical moxibustion combined with Fenmotong can effectively slow down the decline in ovarian reserve,increase AMH level,improve menstrual conditions and patient discomfort,compared with the simple application of Fenmotong.The clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of DOR is better.