Study On The Formula Of Medicated Diet For Insomnia

Objective: Study the prescription law of food therapy diet for insomnia by data mining and construct a syndrome differentiation diet scheme,so as to provide theoretical basis and guidance for the personalized diet care for insomnia patients and the development of food therapy diet products.Methods: On the basis of literature collation and theoretical discussion,the ancient and modern food therapy diet prescriptions related to insomnia in the Great Dictionary of Chinese medicinal diet and the complete record of TCM diet prescriptions were systematically sorted out,the relevant database was established,the frequency statistics of four Qi and five flavors and meridians of diet and medicinal diet raw materials were carried out,and the frequency statistics were carried out by using Microsoft Excel 2016 and traditional Chinese Medicine Inheritance calculation platform(V2.5)Association rules and complex system entropy hierarchical cluster analysis.Result: The dosage forms of 349 prescriptions for insomnia are mainly dishes,beverages and porridge;The syndrome types of food therapy prescriptions are mainly Yin deficiency and fire hyperactivity,deficiency of heart and spleen,disharmony of heart and kidney,internal disturbance of phlegm and fire;There are 243 kinds of raw materials involved in the prescription,including 91 kinds of drugs,93 kinds of food and 59 kinds of functional Food;The four Qi are mostly neutral,warm and cold;The five flavors are mainly sweet;The meridians of the five zang organs are the core,and the spleen are the most.The statistics of common raw materials and drug properties,association rules and entropy cluster analysis were carried out.The top 8 common raw materials of yin deficiency and fire hyperactivity insomnia are tremella,rock sugar,lily,japonica rice,mulberry,jujube,lotus seed and Rehmannia glutinosa;The four Qi of raw materials are mainly neutral and cold,and the five flavors are mainly sweet,which are mainly attributed to the lung meridian;Among the results of association rules,the drug pairs with strong association degree include rock sugar tremella,Lily rock sugar,Rehmannia glutinosa Lily and so on;Unsupervised entropy hierarchical clustering obtained 9 new prescriptions.The top 8 common raw materials of insomnia with deficiency of heart and spleen are longan,reddates,lotus seed,japonica rice,yam,ginseng,glutinous rice and chicken;The four gases of raw materials are mainly neutral and warm,and the five flavors are mainly sweet,which are mainly attributed to the spleen meridian;Among the results of association rules,the drug pairs with strong association degree include longan,red-dates,longan lotus seed,reddates lotus seed,etc;Unsupervised entropy hierarchical clustering is used to get four new formulas.The top 8 common raw materials of heart kidney incompatibility insomnia are medlar,longan,Rehmannia glutinosa,Schisandra chinensis,japonica rice,yam,rock sugar and Polygala tenuifolia;The four feed gases are mainly warm and flat It is mainly composed of neutral and warm drugs,sweet tastes and mainly belongs to the kidney meridians;Among the results of association rules,the drug pairs with strong association degree include longan-medlar,Rehmannia glutinosa-medlar,longan-pigeon egg,angelicamedlar and so on;Unsupervised entropy hierarchical clustering is used to get three new formulas.The top 8 common raw materials of phlegm fire internal disturbance insomnia are osmanthus fragrans,chicken eggs,Gastrodia elata,japonica rice,lotus seeds,white granulated sugar,chrysanthemum and rushes;The four gases of raw materials are mainly neutral and cold,and the flavors are mainly sweet,which are mainly attributed to the spleen meridian;Among the results of association rules,the drug pairs with strong association degree are Osmanthus fragrans-lotus seeds and so on;Unsupervised entropy hierarchical clustering obtains a new square.Conclusion:1.The analysis results of the frequency,drug properties and syndrome types of raw materials commonly used in the food therapy prescriptions for insomnia suggest that the pathogenesis of insomnia is mixed with deficiency and excess,and the syndrome type is mainly deficiency syndrome,which is manifested in the deficiency of Qi,blood,Yin and Yang of the five zang organs.Therefore,most of the raw materials have the effect of tonifying Qi,blood,Yin and Yang,and the excess syndromes are mostly caused by the accumulation of phlegm,food and fire,so the Qi and flavors are mainly cold,bitter and acrid.2.Prescription rules of high-frequency syndrome types: the prescription of yin deficiency and fire prosperity mainly focuses on nourishing Yin and clearing heat,while assisting the products of strengthening spleen and stomach to prevent Yin tonifying drugs from nourishing greasy and hindering the stomach;On the basis of tonifying the Qi and blood of the heart and spleen,the medicated diet formula of deficiency of the heart and spleen is often combined with the product of tonifying the essence of the kidney to promote curative effect;The formula of medicated diet of heart kidney disharmony type is mainly to tonify the Yin essence of liver and kidney,and a small amount of tonifying yang to seek Yin from Yang;The medicinal diet of phlegm fire internal disturbance type is mainly composed of clearing heat and removing phlegm,and the use of light seepage and diuretic drugs gives a way out for the evil of phlegm heat.3.Based on the results of statistics,data mining and analysis of medication law,build a TCM syndrome differentiation food therapy scheme for insomnia to provide a theoretical basis for clinical syndrome differentiation diet for insomnia.