Professor Ni Cheng's Treatment Of Insomnia Group Prescriptions

Objective:Applying the Traditional Chinese Medicine(TCM)Inheritance Support System(V2.5),to retrospectively analysis the treatment cases of professor ni cheng insomnia outpatients,and explore the academic heritage and herbal prescription rules of professor ni cheng how to make diagnosis and give treatment of insomnia.Hope to update the herbal prescription patterns of insomnia.Provide some new reference and thoughts for the clinical diagnosis and treatment of insomnia.Methods:The paper gathers insomnia outpatient cases that professor ni cheng used to remedy from September 1,2012 to December 30,2016.Choose 80 medical cases on the basis of inclusion criteria,a total of 105 diagnosis and treatment numbers.Data entry the TCM inheritance support system to set up a database about symptoms and traditional Chinese medicine of insomnia.The platform is used to extract,statistics and analyze the cases.Through the frequency analysis,association rules and complex systemic entropy types of symptoms and herbal prescription to mining some herbal prescription rules and experiences of professor ni cheng.Results:Through the frequency analysis of symptoms and herbal prescription conclude 211 symptoms and 118 medicines.High-frequency symptoms like difficult to fall asleep,easy to wake up after sleep,dreaminess,upset,shallow sleep,fatigue,easy to anger and so on.High-frequency medicines like spina date seed,keel,selfheal,radix bupleuri,cassia twig,raw oysters,lily,baical skullcap root,peony,gardenia,etc.Based on the association rules analysis got 15 core set pattern groups of symptoms which include difficult to fall asleep,easy to wake up after sleep;easy to wake up after sleep,shallow sleep;shallow sleep,dreaminess;difficult to fall asleep,upset.and 21 pharmaceutical compositions groups like as spina date seed and keel;selfheal and spina date seed;selfheal and keel;cassia twig and keel;cassia twig and spina date seed;lily and spina date seed;radix bupleuri and spina date seed;cassia twig and raw oysters;keel and raw oysters;spina date seed and raw oysters;etc.High relational grade set pattern modes of symptoms include dark red tongue->difficult to fall asleep,chest distress->difficult to fall asleep,shallow sleep->easy to wake up after sleep,shallow sleep->dreaminess,easy to wake up after sleep->difficult to fall asleep,easy to anger->difficult to fall asleep,upset->difficult to fall asleep,easy to anger->easy to wake up after sleep,fatigue->easy to wake up after sleep,etc.High relational grade pharmaceutical compositions include nard->spina date seed;selfheal,lily->spina date seed;lily->spina date seed;gardenia->spina date seed;keel->spina date seed;cassia twig->keel;spina date seed,lily->selfheal;selfheal,keel->spina date seed;raw oysters->cassia twig;cassia twig->spina date seed;etc.Some correlations were got through the association analysis between symptoms and herbal prescription.Spina date seed,cassia twig,selfheal,lily,gardenia,keel and raw oysters often be used to solve symptoms of insomnia itself.Baical skullcap root,radix bupleuri,tortoise plastron,albizia julibrissin,rhizoma pinelliae preparatum,coptis chinensis and peony often be used to solve effects of insomnia like upset,easy to anger,easy to scare and irritability.Keel,nard gardenia and selfheal often be used to solve accompanying symptoms of insomnia like dreaminess,fatigue,bitter taste,etc.Based on the correlation degree analysis between medication and medication,10 kernal combinations and 5 new prescriptions are found by the complex systemic entropy clustering type and non-supervising entropy clustering type for treating insomnia.The main kernal combinations are gardenia_raw oysters_baical skullcap root;salvia miltiorrhiza_sophora flavescens_suncured ginseng;peony_tortoise plastron_selfheal;keel_tree peony bark_selfheal;etc.Main new prescriptions are gardenia_raw oysters_baical skullcap root_stephania tetrandra;salvia miltiorrhiza_sophora flavescens_suncured ginseng_radix adenophorae;peony_tortoise plastron_selfheal_stephania tetrandra;keel_tree peony bark_selfheal_cassia twig_angelica sinensis;etc.Conclusion:1.From the correlation between the symptoms and frequency of symptoms can know the core symptoms of insomnia are difficult to fall asleep,easy to wake up after sleep,dreaminess,upset,easy to anger,etc.Based on the above and the early clinical curative effect observation,professor ni cheng propose insomnia's underlying cause is exhaustion,pathogenesis is wei doer not enter the yin and yang chiao channel vigorous.2.Through the mining analysis of medicines and association analysis between symptoms and herbal prescription found that professor ni cheng's medicine compound ideas for the treatment of insomnia include reinforce yang and nourish yin,dredge qiao channel and mind-tranquilizing,cut-through yin and yang,clearing heat and relieving fidgetness,relieve the depressed liver,etc.Characteristics use of medicine include alternate spina date seed with cassia twig and alternate selfheal with cassia lily which can from yang to yin and cut-through yin and yang.Spina date seed can combine dredging and tonifying to yang qiao channel and ying qiao channel,cassia twig can dredge vessels of wei yang enter into yin.3.Professor ni cheng inherit the academic idea of "monarch disease,main prescription"of professor wang qi.Based on academic thought of smooth the yin yang patency and regulating liver torequiem,professor ni cheng found the treatment from eight extraordinary channels.Which mainly to nourishing yin and yang-enriching,ventilate qiao channel and tranquilizing.Hope can provide a new method for treatment of insomnia.