Study On Professor Jia Xiaoqiang’s Medication Pattern And Treatment Idea Of Chronic Functional Constipation Based On Data Mining

Chronic functional constipation is a common clinical disease.Professor Jia Xiaoqiang’s team has long been focused on the study of CFC and has accumulated rich experience.Data mining is the process of revealing meaningful new relationships,trends,and patterns by carefully analyzing large amounts of data.In this study,we conducted data mining on the clinically effective medical cases of Prof.Jia in the treatment of CFC.It is expected to explore and summarize the academic thought about Prof.Jia on the treatment of CFC.Objective:Based on the data mining,we discussed the medication pattern and Prof.Jia’s idea of treatment about CFC.It is expected to provide a relevant basis and reference for the clinical treatment of CFC.Methods:By using "Excel 2017" and "Traditional Chinese medicine Computing Platform V3.0",the "constipation outpatient special disease registration system" was established and the patients’ treatment information was entered.Based on data mining,we analyzed the four diagnostic information and syndrome distribution of patients with CFC,and explored the medication pattern of Prof.Jia in treating CFC.Results:A total of 278 medical cases of CFC treated effectively by Prof.Jia were included in this study.Among them,207 cases were female and 71 cases were male.The age distribution of the patients was 17～94 years,with a mean age of 59.49±15.87 years,and patients in the age group of 60～69 years were the most common.The patient’s clinical symptoms were straining to defecate and using laxatives or maneuvers to assist in defecation.Patients contained a total of 27 tongue signs and 8 pulse descriptions.The common frequency of tongue signs were dark tongue,dry tongue,and little tongue;the common frequency of pulse signs were fine pulse,sunken pulse,and string pulse.Prof.Jia’s prescription for CFC involved 74 herbs.The medicine is mainly cold,warm and flat,and the medicine taste is mainly bitter,sweet and pungent.The drugs are mostly distributed in the stomach,lung,spleen,large intestine,liver and kidney meridians.The efficacy of TCM is classified as tonifying deficiency drugs(18).The frequency and efficacy of TCM are classified as follows:tonifying deficiency(1730 times),regulating qi(582 times),clearing heat(532 times),and moistening lower part(364 times).The high-frequency drugs used in order were Licorice,Radix Scrophulariae,Magnolia officinalis,Ophiopogon japonicus,Atractylodes macrocephala.The results of association analysis showed that under the parameter setting of 85%confidence level and support degree of 1,there were 114 association rules containing 4 associated base drugs,which were Magnolia officinalis(50),Ophiopogon japonicus(30),Atractylodes macrocephala(18),Radix Scrophulariae(16)in order of frequency;in addition,8 drugs,namely Atractylodes macrocephala,Magnolia officinalis,Radix Scrophulariae,Ophiopogon japonicus,tangerine peel,Angelica sinensis,Fructus aurantii,Astragalus,appeared repeatedly in several association rules.The results of cluster analysis can be divided into 5 categories of prescriptions:(1)Astragalus membranaceus,Atractylodes macrocephala,Radix Scrophulariae,Ophiopogon japonicus,Magnolia officinalis,Fructus aurantii,Angelica sinensis.(2)Ophiopogon japonicus,Radix Scrophulariae,Atractylodes macrocephala,hemp kernel,Fructus aurantii,Angelica sinensis,Rehmannia glutinosa.(3)Betel nut,betel nut,Prunus alba,Chenyu.(4)Atractylodes macrocephala,Magnolia officinalis,Fructus aurantii,neem,tangerine peel,Radix Scrophulariae,bupleurum.(5)Radix Scrophulariae,Atractylodes Macrocephalae,Ophiopogon japonicus,Magnolia officinalis,Fructus aurantii,Angelica sinensis,Cistanche deserticola.There are five kinds of syndrome distribution,and the total frequency of syndrome is 323 times.The first three are Qi and yin deficiency syndrome,yin deficiency and intestinal dryness syndrome,and blood stasis and collateral stagnation syndrome.There were 11 types of treatments distributed,and the total frequency of treatments was 757;the top three in order were benefitting Qi and nourishing Yin,raising Yang and benefiting the kidney,and benefiting Qi and strengthening the spleen.Conclusion:In treating CFC,Prof.Jia attaches the importance of examining the evidence to find the cause and treating the root of the disease.He focuses on the adjustment of qi,blood,yin and yang,and the functions of the internal organs,and advocates the use of tonics to promote bowel movements.He specializes in"Astragalus membranaceus-Raw atractylodes macrocephala","Cohosh-Bupleurum","Fructus aurantii-Magnolia officinalis","Radix scrophulariae-Raw land","Hemp kernel-Cypress kernel","Achyranthes bidentata-Peach kernel","Cistanche deserticola-Suoyang" and other drug pairs.The basic drug combination is composed of Astragalus,Atractylodes macrocephala,Radix Scrophulariae,Ophiopogon japonicus,Magnolia officinalis,Fructus aurantii and Angelica sinensis,and paying attention to the addition and subtraction of drugs with symptoms type.