Analysis Of Asthma Drug Use Based On Modern Literature And Clinical Research

Object: to search the literature of Traditional Chinese Medicine(TCM)prescription,which was published in China from January 1980 to December 2019,on the basis of the asthma,based on the clinical evidence,we analyzed the law of drug use and prescription,combined theory with practice,to understand the characteristics of the whole course syndrome and treatment of asthma,in order to better clinical diagnosis and treatment.Methods: based on the search database of CNKI,this paper analyzed the literature of Asthma published in China from January 1980 to December 2019,first,"asthma;traditional Chinese Medicine" as the search term for the indecisive retrieval,view the text according to the inclusion and exclusion standard to select the required documents.The frequency and factor analysis were carried out by SPSS statistics 25.0,and association rules were carried out by apriori algorithm in SPSS modeler14.0 hrough the respiratory outpatient clinic system of the Tianjin University of Traditional Chinese Medicine,patients with asthma who were prescribed by the chief physician of respiratory outpatient clinic in August 2017 and December 2019 were selected,clinical information such as outpatient number,name,sex,age,date of visit and prescription composition were recorded.To understand the drug use of asthma,to analyze its drug use,composition of the law,with the modern literature part,to analyze the characteristics of asthma syndrome and treatment.Results:1 Literature Review(1)the main drugs used in the treatment of asthma were warm,cold and flat drugs,which accounted for 95.74% of the total drugs.From the perspective of five kinds of drugs,the order of the first three(91.42% of the total)was: Pungent Drugs(5412 times)> Sweet Drugs(5117 times)> Bitter Drugs(4310 times).From the point of view of Meridian Tropism,the main channel to the lung,followed by the spleen,heart,stomach,kidney,liver and other channels.The classification of drug efficacy mainly includes expectorant,antitussive,antiasthmatic and tonic drugs,which account for 50.56%,followed by antipyretic,heat-clearing,astringent,water-disinhibiting and dampness-seeping,liver-calming andqi-regulating drugs.Among them,the most common antitussive and expectorant drugs were antitussive and antiasthmatic drugs,followed by the warm and cold phlegm drugs.According to the frequency distribution of drug properties,the main drug was warm,which was 3.29 times as cold.The most of drugs for tonifying Qi were drugs for tonifying Qi,followed by drugs for tonifying blood.Meridians enter the lungs,spleen and kidneys.Antipyretic drugs are mainly for dispersing wind-cold.Heat-clearing drugs are mainly used to clear away heat and dryness and dampness.Qi-regulating drugs are mainly for regulating Qi and strengthening spleen.(2)the association rules were used to analyze the drugs,and the association items were Ephedra,Pinellia,almond,Schisandra and ginger.;To come up with four basic prescriptions :Er chen Tang,San ao Tang,Xiao qing long Tang,Ding chuan Tang.Through factor analysis,it is found that there are 9 basic prescriptions used in asthma treatment: Jin gui Shen qi Wan,Ding chuan Tang,Xiao qing long Tang,She gan ma huang Tang,Sheng jiang San,Ma xing shi gan Tang,Yu ping feng San,Er chen Tang,and San zi yang qin Tang.2 Clinical Study:the study included a total of 1061 prescriptions,a total of 152 herbs.(1)patients basic information:Asthmatics significantly more women than men,mainly in the age of 50-69 years old.(2)drug analysis: In the four-gas distribution,the drugs used to treat asthma were mainly warm,cold and calm,among which the drugs of warm and cold accounted for45.06% and 32.17% respectively.The frequency of use of pungent drugs(10007 times)was the most,accounting for 36.36%,followed by bitter drugs(32.90%),sweet drugs(23.64%).In the distribution of Meridian Tropism,the main channel of drugs was the lung meridian(55.71%),followed by the spleen,liver,heart and Kidney Meridians.In the efficacy distribution table,the main drugs are expectorant,antitussive,antipyretic,tonic,liver-calming and qi-regulating drugs,and the cumulative frequency is above 90%.Secondly,it contains astringent medicine,Kai qiao medicine,Huo xue hua yu medicine,diuretic,Wen li Medicine,Hua shi medicine,an shen medicine,Qu feng shi medicine,Xiao shi medicine,hemostatic medicine and Catharsis medicine.(3)cluster analysis: Cluster analysis of the first 35 traditional Chinese medicineswhose cumulative frequency accounts for more than 90% of the total drugs,there are four basic prescriptions: Ding chuan Tang + Gan cao she gan jie geng Tang,Xiao qing long Tang,Bu zhong yi qi Tang,Xiang su San.Conclusion:1.The treatment of asthma is centered on "phlegm",which is combined with cold and warm drugs,and advocates "warming" and "clearing".2.The main pathogenic factor of asthma is to feel exogenous pathogenic factors,and the treatment methods of wind-dispelling,surface-clearing,cold-dispelling and evil-dispelling play an important role in the treatment of asthma.3.The first place to treat asthma is in the lung,and the second place is in the spleen(stomach).It can be known that,in addition to the treatment of disease itself in the viscera,but also pay attention to regulating and tonifying the Middle Energizer,not only preventing phlegm from disturbing the lung,but also tonifying the kidney.Therefore,the treatment of supporting the body and dispelling pathogenic factors can not be ignored.