Analysis Of Professor Lu Bingjiu's Clinical Experience In Treating Primary Biliary Cholangitis Based On Data Mining

Purpose:Based on data mining method and clinical experience,this paper analyzes the clinical manifestations of patients with primary biliary cholangitis(hereinafter referred to as PBC)and the differences of prescriptions,and summarizes the medication rules of Professor Lu Bingjiu in the treatment of primary biliary cholangitis,so as to provide new ideas for the future TCM treatment of the disease.Materials and methods: a total of 169 patients with PBC who were first diagnosed in the liver disease clinic of Affiliated Hospital of Liaoning University of traditional Chinese medicine were collected,and the patient's medical record information database was established.By using descriptive statistical analysis,association rule analysis and other modern statistical methods,the differences in clinical manifestations and medication prescriptions were compared,and the characteristics,meridian tropism and functions of traditional Chinese medicine used by Professor Lu Bingjiu in the treatment of PBC were summarized To explore the similarities and differences of syndrome differentiation and treatment between different TCM diagnosis.Results: a total of 180 patients with PBC were collected.According to the inclusion criteria and exclusion criteria,11 patients who did not meet the inclusion criteria were excluded,and169 patients were effectively enrolled.1.General data analysis results: women accounted for a large proportion,130 women and 39 men,the ratio of men and women was about 1:3.33.The age range of male is 18-83 years old,and that of female is 24-81 years old.The average age of male is 53.6 years old,and that of female is 55.1 years old.2.Symptom analysis results: there were 61 kinds of accompanying symptoms in 169 patients,with a total frequency of 609 times.The symptoms with a frequency of more than 10% were:poor sleep,fatigue,dry mouth,hypochondriac pain,swelling of lower limbs,jaundice,joint pain,itching skin,loose stool,abdominal distension,anorexia,epigastric discomfort,dry eyes.3.TCM diagnosis and analysis results: 169 patients were diagnosed with 10 kinds of diseases,the first three kinds of diagnosis were hypochondriac pain(39 cases),jaundice(31 cases)and edema(25 cases).4.Results of drug frequency analysis: a total of 158 traditional Chinese medicines were used,with a total frequency of 2717 times.Baizhu(135),Chenpi(133),Fuling(101),Jineijin(94),Danggui(89),Gancao(67),Atractylodes lancea(65),Houpu(64),Guizhi(62),Huangqi(61)were the top ten herbs used frequently.5.Analysis of nature,taste and meridians: the top three properties of traditional Chinese medicine were warm,cold and flat.The top three most frequently used herbs were sweet taste(34.16%),bitter taste(29.57%)and pungent taste(23.25%).The main channel of drugs was spleen channel,followed by liver,stomach and lung channel.In terms of drug efficacy,the order of frequency of use is: Qi tonifying drugs > Qi regulating drugs > diuretic drugs > blood tonifying drugs > Xiaoshi drugs > heat clearing drugs > blood activating drugs.6.Six core drug groups were obtained by association rules analysis: the core prescriptions of hypochondriac pain were bupleurum,Fructus aurantii,Cyperus,tangerine peel,Poria cocos,Atractylodes macrocephala,Magnolia officinalis,Paeonia lactiflora,Angelica sinensis and Radix Glycyrrhizae;the core prescriptions of jaundice were Herba Artemisiae,Poria cocos,Atractylodes macrocephala,Radix paeoniae rubra,Radix Aconiti Lateralis,plantaginis,Radix et Rhizoma,Pericarpium Citri Reticulatae Reticulatae;the core prescriptions of edema were Poria cocos,Ramulus Cinnamomi The core prescriptions of dryness syndrome were Angelica sinensis,radix rehmanniae,Radix Astragali,Radix Codonopsis,Radix Ophiopogonis,radix rehmanniae,Fructus Lycii,Rhizoma Atractylodis Macrocephalae,Poria cocos,Pericarpium Citri Reticulatae,and Radix Jineijin;the core prescriptions of blood syndrome were Pericarpium Citri Reticulatae,Rhizoma Atractylodis Macrocephalae,cortex Jineijin,Panax notoginseng,cuttlebone,Radix sanguisorbiae,Radix Platycladus charcoal;the core prescriptions of itching syndrome were Angelica sinensis,Radix Astragali,Rhizoma Atractylodis Macrocephalae,and Radix cangneijin It is composed of three parts: Atractylodes rhizome,Saposhnikovia divaricata,cicada slough,Schizonepeta tenuifolia,roasted licorice.Conclusion:1.PBC patients are mainly middle-aged women,the location of the disease is in the liver,spleen and kidney,which can involve the gallbladder,stomach,lung,heart and other organs.The pathological factors include qi stagnation,blood stasis,dampness,essence deficiency and so on.The pathogenesis is mostly mixed with deficiency and excess,and essence deficiency runs through the whole process of the disease.2.Lu Shi's medicine was mainly composed of warm and sweet nature and mild property.His prescription focused on "Qi blood coordination,reinforcing and reducing,and giving consideration to both liver and spleen".3.According to the different symptoms and pathogenesis,PBC belongs to different diseases,but the treatment principle of "tonifying essence and replenishing qi,promoting diuresis and dampness,regulating qi and activating blood circulation" embodies the treatment idea of "treating different diseases with the same treatment";however,according to the different symptoms,the treatment idea of "treating the same disease with different treatment" is embodied.