The Effect Of Mogrosides Intervention On The Level Of Related Indexes Of Delayed Onset Muscle Soreness

When the body does not adapt to the heavy load exercise,it is easy to cause Delayed Onset Muscle Soreness(DOMS).At present,there are a variety of prevention and treatment measures for DOMS,but it is difficult for any of them to achieve an ideal effect.Therefore,this study further carried out relevant research.Objective:To observe the effects of Mogrosides intervention on the degree and muscle injury,inflammation and function changes during the DOMS process,and to explore the relationship between the improvement of anti-oxidation ability of the body and the change of DOMS related indexes.Methods:16 healthy male young students,were randomly divided into control group(CG,n=8)and the experimental group(EG,n = 8),CG with placebo intervention,EG using intervention of Mogrosides,CG po placebo and EG poMogrosides,after 27 d,leapfrogging of the same quantitative load training,and then continue respectively to placebo or Mogrosides of 3d.Visual analogue scale(VAS)was used to measure the degreeof subjective pain perception in eachgroup beforepre-drug,pre-exercise,post-exercise,24 h after exercise,48 h after exercise and 72 h after exercise.At the same time,the activities of Creatine Kinase(CK)and Creatine Kinase Isozyme-MM(CK-MM),Total Antioxidant Capacity(T-AOC)and Malondialdehyde(MDA)of the above phase serum were detected,the plasma interleukin-6(IL-6)concentration and the surround degree of the junction between the middle and lower 1/3 of the thigh were detected,and the maximum isometric muscle force of lifting the thigh and active range of motion(AROM)of the knee joint were detected.Results:(1)Changes in the degree of subjective pain perception: the data pre and after exercise were analyzed,and the interaction between time and group was significant(P< 0.05).In the post-event time effect analysis alone,both groups continued to increase after exercise,but the EG reached the peak at 48 h after exercise,and the index level of all the time phases after exercise was higher than that pre-exercise(P < 0.05),andthe index level post-exercise was lower than that of other phases after exercise(P <0.05).In group effect analysis alone,EG was lower than CG at 72 h after exercise(P <0.05).(2)Changes in maximum isometric muscle force of lifting the thigh: the data pre and after exercise were analyzed,and the interaction between the time and the group was significant(P < 0.05).The post-exercise time effect analysis alone showed that the index levels of CG and EG were lower post-exercise,24 h after exercise and 48 h after exercise than pre-exercise(P < 0.05).In group effect analysis alone,the indicator level of EG at 24 h and 48 h after exercise was higher than CG(P < 0.05).(3)Changes of knee joint AROM: the data pre and after exercise were analyzed,and the main time effect was significant(P < 0.05).The index levels of both groups continued to decline after exercise,among which the index levels at 24 h after exercise,48 h after exercise and 72 h after exercise were all lower than those pre-exercise(P <0.05).(4)Changes in plasma IL-6 concentration and the surround degree of the junction between the middle and lower 1/3 of the thigh: the data before and after exercise were analyzed,and the time and group interaction was significant(P < 0.05).The time effect analysis alone showed that the levels of CG and EG at 24 h,48h and72 h after exercise were higher than those pre-exercise(P < 0.05).In the group effect analysis alone,the two indicators of CG were higher than EG at 72 h after exercise(P< 0.05).(5)Changes in serum CK and CK-MM activity: the data pre and after exercise were analyzed,and the interaction between time and group was significant(P < 0.05).The two indexes in each group were higher than that pre-exercise(P < 0.05),and the highest at 48 h after exercise.In group effect analysis alone,the levels of EG at 24 h,48h and 72 h after exercise were lower than those of the control group(P < 0.05).(6)Changes of serum T-AOC and MDA contents: the level of EG pre-exercise was higher than that pre-drug in the group(P < 0.05),and the level of EG preexercise was higher than that pre-drug in the group(P < 0.05).To each phase of the data pre and after exercise were analyzed,and the interaction time and group significantly(P﹤0.05),after the time effect analysis alone,after exercise all phase level of two indicators are higher than pre-exercise(P﹤ 0.05),the T-AOCpeak of EGat post-exercise,and T-AOC peak of CG at 48 h after exercise,MDA content peak of EG and CG all at 48 h after exercise;In group effect analysis,the T-AOC and MDAcontent of EG in each phase after exercise were higher and lower than those in the control group(P < 0.05).Conclusion:Mogrosides intervention can improve the body’s antioxidant capacity,and then may reduce the peroxidation damage of muscle tissue,to control the muscle inflammation,swelling and the development of DOMS.The Mogrosides intervention can promote the recovery of muscle force during DOMS.