Clinical Observation On Zhishi Xiaopi Pills Plus Or Minus Prescription Combined With Traditional Chinese Medicine Hot Ironing In Treating Senile Functional Constipation(Spleen Deficiency And Qi Stagnation Type)

Objective: By observing the clinical effect and drug safety of Zhishi Xiaopi Pill plus or minus prescription combined with hot ironing of traditional Chinese medicine on functional constipation(spleen deficiency and qi stagnation type)in the elderly,it provides a new idea for the treatment of functional constipation in the elderly by Internal and external combined treatment of traditional Chinese medicine.Methods: To collect 80 elderly patients with functional constipation(spleen deficiency and qi stagnation type)who met the inclusion criteria among inpatients in the senior cadres department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine.A stratified randomization method was adopted.First,80 patients were stratified according to gender,age,and disease course,and then randomized within each strata.Finally,they were divided into treatment group and control group at a ratio of 1:1,with 40 cases each.The treatment group was given Oral Zhishi Xiaopi Pills plus or minus prescription,combined with traditional Chinese medicine hot ironing,and the control group was given Polyethylene Glycol 4000 Powder orally,the course of treatment was both 2 weeks.Observe and record the Wexner constipation symptom scores and TCM syndrome scores of constipation in the two groups before treatment,after 1 week and 2 weeks of treatment,and record the changes in safety indicators and adverse events.One month after the end of the treatment course,the patient was followed up for recurrence of constipation.And SPSS 21.0 was used to the statistical analysis of the collected data to evaluate the final clinical efficacy.Results:(1)Evaluation of efficacy of constipation symptoms:The total effective rate of the treatment group after 2 weeks of treatment was 92.3%,while that of the control group was 73.0%.The results showed that the treatment group was better than the control group in terms of constipation symptoms(P<0.05);(2)Evaluation of curative effect of TCM syndromes of constipation:The total effective rate of the treatment group after 2 weeks of treatment was 94.9%,while that of the control group was 70.3%.The results showed that the treatment group was better than the control group in the efficacy of TCM syndromes of constipation(P<0.01);(3)Wexner constipation symptom total scores:Both the treatment group and the control group improved the total scores of Wexner constipation symptoms(P<0.01),and after 2 weeks of treatment,the improvement is more obvious than 1 week of treatment.Overall,compared with the control group,the treatment group improved significantly on the total scores of Wexner constipation symptoms(P<0.01),and the curative effect was better.(4)Total scores of TCM syndromes of constipation:Both the treatment group and the control group improved the total scores of TCM syndromes of constipation(P<0.01),and the improvement effect was more obvious after 2 weeks of treatment than after 1 week of treatment.Overall,compared with the control group,the treatment group improved significantly in the total scores of TCM syndromes of constipation(P<0.01),and the curative effect was better.(5)Wexner constipation single symptom scores:After 1 week and 2 weeks of treatment,both the treatment group and the control group improved in the scores of other individual symptoms except the total time of constipation(P<0.05).On the whole,the treatment group was better than the control group in terms of Wexner constipation single symptom scores(P<0.05).(6)Single scores of TCM syndromes of constipation:After 1 week and 2 weeks of treatment,both the treatment group and the control group could improve the single scores of TCM syndromes of constipation(P<0.05).On the whole,the treatment group was more effective than the control group on the single scores of TCM syndromes of constipation(P<0.05).(7)Safety:Before and after treatment,the safety observation indicators of the two groups of patients generally tended to the normal range.During the course of treatment,the incidence of adverse reactions in the control group was 10.8%,while that in the treatment group was 2.6%.There was no significant difference between the two groups(P>0.05).(8)Short-term recurrence rate:One month after the end of the treatment course,the short-term recurrence rate of the follow-up control group was 44.4%,and that of the treatment group was 19.4%.The short-term recurrence rate of the treatment group was lower than that of the control group(P<0.05).Conclusion: Zhishi Xiaopi Pills plus or minus prescription combined with traditional Chinese medicine hot ironing can improve the clinical symptoms of functional constipation of spleen deficiency and qi stagnation in the elderly,and the incidence of adverse reactions and recent recurrence rates are low,and it is clinically safe and effective.