Analysis Of Risk Factors,TCM Constitution And Syndrome Elements In Patients With Symptomatic Atherosclerotic Stenosis TIA

Objective: Ischemic stroke（ICS）is one of the top five fatal diseases in the world,and transient ischemic attack（TIA）,a special type of acute cerebrovascular disease,is also the most important independent risk factor of ICS.The presence of TIA indicates a strong potential for ICS.Through a control study of PATIENTS with TIA caused by cerebral artery stenosis and healthy people,this study explored and analyzed the distribution of TCM syndrome elements,TCM constitution and controllable risk factors of cerebral atherosclastic stenosis,in order to provide a theoretical basis for the prevention of TIA and ICS for clinicians conducting studies on encephalopathy in TRADITIONAL Chinese medicine.Methods :This study is based on the special project of The National Clinical Research Base of Traditional Chinese Medicine--"Study on risk factor Screening and TCM Syndrome Regularity of Patients with Symptomatic Cerebral Perfusion Artery Stenosis"（project number: JDZX2015295）.The research method of this study is the randomized control method,144 cases were selected as the subjects of this study.The patients were divided into observation group（90cases）and control group（54 cases）.According to the distribution of main cerebral artery blood supply,the observation group was divided into two subgroups: internal carotid artery system subgroup and vertebrobasilar artery system subgroup 45 cases.For all the study subjects,the relevant data of TCM and Western medicine and auxiliary examinations were collected,and the Diagnosis Scale of TCM Syndrome Elements and Self-test Table of TCM Constitution and Discrimination were collected for each patient.SPSS 19.0statistical software was used to analyze the obtained data.The statistical description of the measured data followed or was close to the normal distribution with standard deviation ± mean（x±s）,and t test was adopted.The X2 test was used for counting data.When the total number of cases n≥40 and 1≤T < 5 with a grid,the X2 test of continuity correction was used for analysis.In the observation group,the risk factors of internal carotid artery subgroup and vertebrobasilar artery subgroup and the correlation analysis of traditional Chinese medicine constitution were analyzed by Logistic regression analysis with non-conditional dictation data.The relevant data were calculated and analyzed.When P < 0.05,it was statistically significant.After the conclusion of statistical method,combined with the professional knowledge of the department of encephalopathy for analysis.Results:1.Distribution of syndrome elements: the frequency of phlegm turbidity and blood stasis was high in the observation group,and the frequency of Qi deficiency,Qi stagnation,Yin deficiency and heat was common;The syndrome factors of the two observation groups were evaluated respectively,and P > 0.05,indicating that there was no significant correlation between the TCM syndrome factors and the site of vascular stenosis.2.Controllable risk factors: In the observation group,the frequency of hypertension,diabetes and dyslidemia was high,while the frequency of smoking,alcohol abuse and homocysteinemia was common;Univariate analysis of risk factors was conducted for the two subgroups included in the observation,and it was concluded that P of each risk factor was > 0.05,indicating that there was no correlation between each risk factor and the site of cerebrovascular lesions.3.Constitution characteristics of TCM: In the observation group,the phlegm-dampness constitution and blood stasis constitution accounted for more,and the proportion of peace quality was the least;in the control group,the proportion of peace quality was the most,and the proportion of special quality was the least;The proportion of patients with phlegm dampness and blood stasis in the observation group was significantly higher than that in the control group,and the number of patients with phlegm dampness and blood stasis in the observation group was significantly lower than that in the control group（ALL P < 0.05）.Chi-square test was conducted on the frequency of various biased constitution in the observation group and the control group,and single factor analysis of traditional Chinese medicine syndrome was conducted for the two subgroups included in the observation.All P > 0.05 indicated that there was no correlation between the physical factors and the cerebrovascular lesion sites.Conclusion 1.Among the TCM syndrome elements of TIA patients caused by atherosclastic stenosis,the most frequent occurrence is phlegm turbidity and blood stasis,followed by qi deficiency,indicating that the etiology and pathogenesis of TIA patients are related to phlegm turbidity,blood stasis and Qi deficiency,and there is no significant correlation with the site of vascular stenosis.2.Among the controllable risk factors of TIA patients caused by atheroscleroascular stenosis,hypertension,diabetes and dyslipidemia were the most common,followed by smoking and alcohol abuse,which showed a positive correlation with the occurrence of TIA,indicating that the controllable risk factors of TIA were hypertension,diabetes,dyslipidemia,smoking and alcohol abuse.There was no significant relationship between the risk factors and the location of vascular stenosis.3.Among the traditional Chinese medicine constitutions of TIA patients caused by atheroscleroascular stenosis,phlegm-dampness constitutions and blood stasis constitutions were the majority,and were positively correlated with them;The moderate quality was the least,showing a negative correlation with the occurrence of TIA,indicating that changing the phlegm-dampness constitution and blood stasis constitution can play a role in preventing THE occurrence of TIA,and the location of vascular stenosis has no obvious relationship with the physical factors,while achieving moderate quality is one of the goals to prevent the occurrence of TIA.4.In the prevention and treatment of ISC and TIA,intervention can be carried out for hypertension,diabetes,dyslidemia,smoking and alcoholism,and the phlegm-dampness constitution and blood stasis constitution can be adjusted to moderate quality.