The Analysis Of The Relationship Between Risk Factors,TCM Constitution And TCM Syndrome Elements Of Symptomatic Vertebrobasilar Atherosclerotic Stenosis

Objective Symptomatic vertebrobasilar atherosclerotic stenosis usually characterize posterior circulation ischemic symptoms predominantly transient ischemic attack and ischemic cerebral stroke.Its clinical manifestations are complex and changeable,and its diagnosis is not easy.In addition to these,its Recurrence rate,fatality rate and disability rate are higher than other types of stroke,and have a poor prognosis.The purpose of this paper is to analyse the distribution characteristics between risk factors,TCM constitution and TCM syndrome elements of symptomatic vertebrobasilar atherosclerotic stenosis,and to seek the internal relationship between TCM Syndrome Elements and TCM etiology and pathogenesis of symptomatic vertebrobasilar atherosclerotic stenosis,and to depth analyse the correlation between the occurrence of symptomatic vertebrobasilar atherosclerotic stenosis and interventional risk factors and TCM constitution,with a randomized controlled study between patients with symptomatic vertebrobasilar atherosclerotic stenosis and healthy people.It may provide a theoretical basis for the TCM etiology and pathogenesis of symptomatic vertebrobasilar atherosclerotic stenosis,and an objective basis for prevention of symptomatic vertebrobasilar atherosclerotic stenosis from interventional risk factors and TCM constitution.Methods This study is a part of the research project of“Risk factors screening and TCM syndrome regularity of symptomatic cerebral perfusion artery stenosis”,which is a special research topic of the national administration of traditional Chinese medicine,the national clinical research base of Chinese medicine.In this study,100 research objects are divided into experimental group and control group,adopting randomized block method.According to the manifestation of the disease,experimental group is divided into ischemic cerebral stroke group and transient ischemic attack group.Collecting general data,past history,Personal history,family history,TCM four diagnostic information symptoms,color doppler Ultrasound,TCD,head and neck Imaging,laboratory examination,etc of all subjects at the time of enrollment.Meanwhile,all subjects fill in ischemic stroke syndromes diagnostic scale and TCM constitution selftest table.The data of this study are analyzed by SPSS 17.0 statistical software.The statistical descriptions of the measurement data obeying or approximating normal distribution are made by (?)±s,adopting ttest,the counting data uses Chisquare test and Pearson Chisquare test.The correlation analysis between risk factors and TCM constitution of transient ischemic attack and ischemic cerebral stroke adopt Logistic regression analysis of unconditional bicategorized Data.All data analysis showed significant difference with P<0.05.On the basis of statistical analysis and combined with the knowledge in this field,the reasonable scope of discussion is carried out.Results 1.In transient ischemic attack group,the frequency of Qi deficiency and phlegm turbidity in TCM constitution is the highest,followed by blood stasis,Qi stagnation,heat and yin deficiency are less.In ischemic cerebral stroke group,internal wind,phlegm and dampness,blood stasis in TCM constitution accounted for the highest proportion,while internal fire,Yin deficiency and Qi deficiency are less.2.In transient ischemic attack group,risk factors such as hypertension,diabetes mellitus and dyslipidemia are the most frequent,and the proportion of phlegmdampness and phlegmdamp ness in TCM constitution is the highest.The proportions of hypertension,diabetes mellitus,dyslipidemia,smoking,alcoholism,hyperhomocysteinemia,Qi deficiency and phlegmdampness in transient ischemic attack group are higher than those of the control group,with statistical differences(P<0.05),while the proportions of gentle quality are lower than those in the control group,with statistical differences(P<0.05).Hypertension,diabetes mellitus,dyslipidemia,smoking,alcoholism,Qi deficiency and phlegmdampness are positively correlated with the occurrence of transient ischemic attack(P<0.05),while gentle quality is negatively correlated with the occurrence of the disease(P<0.05).3.In ischemic cerebral stroke group,the proportion of risk factors such as diabetes,hypertension and dyslipidemia is the highest,and the proportion of phlegmdampness and bloodstasis in TCM constitution is the highest;the proportion of hypertension,diabetes,dyslipidemia,smoking,phlegmdampness and BloodStasis in TCM constitution is higher than that in control group,with statistical difference(P<0.05);and the proportion of gentle quality is lower than that in control group,with statistical difference(P<0.05).Hypertension,diabetes mellitus,dyslipidemia,smoking,phlegmdampness and blood stasis are positively correlated with the occurrence of ischemic cerebral stroke(P<0.05),while gentle quality is negatively correlated with the occurrence of ischemic cerebral stroke(P<0.05).Conclusion 1.Although the TCM syndromes of transient ischemic attack group and ischemic cerebral stroke group are different,they are closely related to deficiency,phlegm,blood stasis and wind from the point of view of the most frequent syndromes,which indicates that the TCM etiology and pathogenesis of symptomatic vertebrobasilar atherosclerotic stenosis are related to deficiency,phlegm,blood stasis and wind.2.Diabetes mellitus,hypertension,dyslipidemia and smoking accounted for a high proportion in the experimental group and are positively correlated with the occurrence of disease,which is an intervening risk factor for symptomatic vertebrobasilar atherosclerotic stenosis.3.Qi deficiency and phlegmdampness are positively correlated with the occurrence of transient ischemic attack,and phlegmdampness and blood stasis are positively correlated with the occurrence of ischemic stroke.This indicates that the constitution of patients with symptomatic vertebrobasilar atherosclerotic stenosis is is mainly phlegmdampness,blood stasis and Q i deficiency,gentle quality is a protective factor for symptomatic vertebrobasilar atherosclerotic stenosis.4.In the process of prevention and treatment of symptomatic vertebrobasilar atherosclerotic stenosis,we can not only intervene in diabetes,hypertension,dyslipidemia,smoking and other risk factors,but also change Qi deficiency,phlegmdampness and blood stasis into gentle quality,so as to achieve the purpose of prevention and treatment of diseases based on constitution.