Association Of Maternal Second Trimester Night Sleep Duration And Sleep Quality With The Risk Of Gestational Diabetes Mellitus

Objective : Gestational diabetes mellitus(GDM)is one of the most common pregnancy complications during pregnancy.In recent years,the prevalence of GDM has shown an increasing trend.The prevalence of GDM in China from 2010 to 2017 was between 5.12% and 33.3%.Sleep disturbances in pregnant women are very common.Studies have shown that sleep is related to the risk of GDM.To explore the relationship between the sleep duration and sleep quality of women in the second trimester of pregnancy and GDM.We performed an epidemiology investigation to evaluate the relationship of maternal second trimester night sleep duration and sleep quality with the risk of GDM.These findings can strengthen the scientific background for public health interventions for the sleep duration and sleep quality.Methods:This study based on the maternal-child-adolescent cohort of the National Key R&D Program of China Northeast Cohort Study.The pregnant women were enrolled by Shengjing Hospital of China Medical University for 75 g oral glucose tolerance test(OGTT)from December 2018 to January 2020.In this study,1914 pregnant women who included.Collect information through questionnaire surveys and biochemical examinations.Information on sleep duration and sleep quality was assessed using the Pittsburgh Sleep Quality Index(PSQI).The general statistical description,logistic regression analysis and stratified analysis were performed using SAS 9.4 to evaluate the association of maternal second trimester sleep duration and sleep quality with the risk of GDM.Results:In this study,a total of 1914 women in second trimester were enrolled in this study,with a prevalence rate of 20.90%.Compared with pregnant women in the non-GDM group,the GDM group had statistically significant differences in age,pre-pregnancy BMI,first pregnancy,history of miscarriage,and family history of diabetes.The logistic regression analysis showed the association of night sleep duration and sleep quality with the risk of GDM were not statistically significant(P>0.05).Stratified analysis showed that in pregnant women who are 35 years old pregnancy,compared to 7-9 hours of night sleep duration,night sleep duration of >9hours group had a slightly decreased risk of GDM(OR<0.001,95%CI:0.00-0.54.In pregnant women who were in depression,night sleep duration of >9 hours group had75%(OR=0.25,95%CI: 0.04-0.96)decreased risk of GDM.When sleep duration and sleep quality were combined,participants with a night sleep duration <7 hours and good sleep quality group had a 4.77-fold increased risk of GDM(OR=5.77,95%CI2.07-17.46),compared with a sleep duration 7-9 hours and good sleep quality group Conclusion:1.Night sleep duration was not statistically associated with the risk of GDM.However,in women who were ≥ 35 years old or in depression,night sleep duration >9 hours was protective factors for GDM.2.Sleep quality was not related to GDM in women in the second trimester.