The Study On The Association Of Sleep Duration And Metabolic Diseases

Object:Sleep is a biobehavioral phenomenon that plays an important role of maintaining body homeostasis.In recent years,the sleep duration of people is decreasing,and almost 20% people suffer from insomnia.suboptimal sleep duration,especially short sleep,has increasingly been shown to represent an additional behavioral factor affecting public health.In recent years,with the development of economy and change of lifestyle,the incidence of metabolic diseasessuch as obesity,diabetes mellitus(DM),nonalcoholic fatty liver disease(NAFLD)and metabolic syndrome are increasing,and than caused a great economic burden.As common metabolic diseases,DM and NAFLD have serious impacts on human health.A number of studies have confirmed that reasonable sleep time is one of the important factors to maintain the metabolic stability of the body,and suboptimal sleep duration may be a risk factor of DM,NAFLD and other metabolic diseases.But as the results of current research are not uniform and the sample size is generally small,the association of sleep duration and metabolic diseases is unclear.We conducted a population-based cross-sectional study in Chongming District,with a total of 9316 participants who participated in the REACTION study.In the present study,we analyzed the association of sleep duration with DM and NAFLD,and then discussed the possible mechanism of sleep duration affecting the glycolipid metabolism.Methods:We selected volunteers(n=9316)who participated in the REACTION study and sorted out the clinical data.Group by sleep duration,we compared the metabolic parameters and calculated the incidence of DM and NAFLD of each group to analyze the the association of sleep duration with DM and NAFLD.ELISA methods were used to investigate the levels of plasma C reactive protein(CRP)and adiponectin.Results:Part 1 the association of sleep duration with diabetes1.The sleep duration of DM group was longer than prediabetes group and normal glucose tolerance(NGT)group(P<0.01);the sleep duration of prediabetes group was longer than normal glucose tolerance group(P<0.01);the levels of plasma CRP and adiponectin between three groups were significant differences(P<0.01).2.The incidence of DM for sleep duration of less than 7h,7-8h,8-9h,9-10 h and 10 h or longer were 22.47%,24.19%,25.29%,27.04% and 29.43%(P<0.01);the levels of plasma CRP and adiponectin in different groups were significant differences(P<0.01).3.The partial correlation analysis showed that sleep duration was significantly and positively correlated with fasting plasma glucose(r=0.251,P <0.05),2-hour post-meal plasma glucose(r=0.262,P <0.05),Haemoglobin A1c(r=0.214,P <0.05)and CRP(r=0.578,P <0.05);and sleep duration was significantly and negatively correlated with adiponectin(r=-674,P<0.05).4.The multiple linear regression analysis showed that sleep duration was a independent risk factor for fasting plasma glucose.5.The logistic correlation analysis showed that risk(odds ratio and 95% confidence interval)of DM for sleep duration of 10 h or longer was 1.323(95%CI1.089-1.607,P<0.05)in female.Part 2 the association of sleep duration with nonalcoholic fatty liver disease1.The sleep duration of NAFLD group was longer than control group(P<0.01);the levels of plasma CRP and adiponectin between two groups were significant differences(P<0.01).2.The incidence of NAFLD for sleep duration of less than 7h,7-8h,8-9h,9-10 h and10h or longer were 38.27%?40.47%?42.35%?44.49%?46.30%(P<0.01);the levels of plasma CRP and adiponectin in different groups were significant differences(P<0.01).3.The partial correlation analysis showed that sleep duration was significantly and positively correlated with triglyceride(r=0.235,P <0.05),gamma-glutamyltransferase(r=0.354,P <0.05),CRP(r=0.578,P<0.05);and sleep duration was significantly and negatively correlated with adiponectin(r=-674,P<0.05).4.The multiple linear regression analysis showed that sleep duration was a independent risk factor for triglyceride.5.The logistic correlation analysis showed that risk(odds ratio and 95% confidence interval)of NAFLD for sleep duration of 9-10 h,10h or longer were 1.378(95%CI1.098-1.728,P<0.05),1.528(95%CI 1.082-2.159,P<0.05)in male.Conclusions:1.Sleep duration is associated with the glucose metabolism,and with the increasing of sleep duration,the levels of FPG,2h PG,Hb A1 c are becoming higher.In female,sleep duration 10h/d or longer is an independent risk factor for DM.2.Sleep duration is significantly and positively correlated with triglyceride,and sleep duration 9h/d or longer is an independent risk factor for NAFLD in male.3.the level of CRP is becoming higher with the increasing of sleep duration while the level of adiponectin is reducing.We estimate that long sleep duration induces chronic inflammatory status,and it may be a potential mechanism resulting in glycolipid metabolism disorder.