| Research purpose: To investigate the effectiveness of heat-sensitive moxibustion on the improvement of related symptoms in elderly patients with acute myeloid leukemia(non-M3)after chemotherapy by observing the intervention effect of heat-sensitive moxibustion with external treatment of traditional Chinese medicine,and to provide clinical basis for the treatment of heat-sensitive moxibustion in elderly patients with acute myeloid leukemia(non-M3)after chemotherapy.Methods: A total of 46 elderly patients with acute myeloid leukemia who met the criteria were selected and randomly divided into experimental group and control group,23 cases in each group.The control group was given demethylation chemotherapy,the experimental group on the basis of chemotherapy plus heat-sensitive moxibustion treatment,heat-sensitive moxibustion selected points for Dazhui,Geshu,Shenshu,Pishu,Weishu,heat-sensitive moxibustion treatment from the first day of chemotherapy,1 times a day,each time for the disappearance of thermosensitive phenomenon,continuous treatment to the 21 st day of chemotherapy;Both groups were given antinausea,stomach care,liver care,and other symptomatic supportive treatment such as anti-infection and blood transfusion when necessary.TCM symptom scores of patients in the two groups were recorded before chemotherapy,the 14 th day of chemotherapy and the 21 st day of chemotherapy,respectively.Blood cell counts included white blood cell count,neutrophil count,hemoglobin count and platelet count.Quality of life scores before chemotherapy and on the 14 th day of chemotherapy;Transfusion volume of erythrocyte suspension and platelet monopheresis during treatment;The difference of data between groups before and after treatment was statistically compared.Results:1.TCM symptom score: the comparison of bone pain symptom score within the group showed no statistical significance except that the experimental group on the 21 st day of chemotherapy was significantly lower than that on the 14 th day of chemotherapy(P<0.05);The comparison of bone pain scores between the two groups on the 14 th and21st day of chemotherapy showed no statistical significance(P>0.05),indicating that heat-sensitive moxibustion did not significantly improve the symptoms of bone pain.On the 14 th day of chemotherapy,the scores of ecchymosis,dizziness,fatigue and poor tolerance in both groups were increased compared with those before chemotherapy(P<0.05).It showed that chemotherapy aggravated the symptoms of ecchymosis,dizziness,fatigue and poor tolerance in the two groups.The scores of ecchymosis,dizziness,fatigue and poor tolerance in the two groups on the 21 st day of chemotherapy decreased compared with the 14 th day of chemotherapy,but there was no statistical significance in the poor tolerance in the control group(P>0.05).The symptoms of ecchymosis,dizziness,fatigue and poor tolerance in the experimental group on the 14 th and 21 st days of chemotherapy were better than those in the control group(P<0.05),indicating that heat-sensitive moxibustion can effectively improve the symptoms of ecchymosis,dizziness,fatigue and poor tolerance.The scores of fever symptoms increased in both groups on the 14 th and 21 st day of chemotherapy,but there was a statistical difference only in the control group that the scores on the 14 th day of chemotherapy were significantly higher than those before chemotherapy,indicating that chemotherapy could aggravate patients’ fever symptoms.The scores of fever symptoms in the experimental group on the 14 th and 21 st day of chemotherapy were lower than those in the control group(P>0.05 on the 14 th day of chemotherapy,P<0.05 on the 21 st day of chemotherapy).It shows that heat-sensitive moxibustion can improve the symptoms of fever.The total symptom score of TCM was the sum of all symptom scores.On the 14 th day of chemotherapy,the total symptom score of TCM in the two groups increased significantly(P<0.05),indicating that chemotherapy would aggravate patients’ discomfort symptoms.The total scores of TCM symptoms in the two groups on the 21 st day of chemotherapy decreased compared with the 14 th day of chemotherapy(P<0.05 in the experimental group,P>0.05 in the control group),and the symptoms of discomfort were reduced on the 21 st day of chemotherapy,but not significantly in the control group.The total scores of TCM symptoms in the experimental group on the 14 th day of chemotherapy and the 21 st day of chemotherapy were significantly lower than those in the control group(P<0.05),indicating that heat-sensitive moxibustion can improve the overall discomfort symptoms of patients.2.Comparison of efficacy of traditional Chinese medicine: compared with the 14 th day of chemotherapy,symptoms of traditional Chinese medicine were improved on the21 st day of chemotherapy.The effective rate of the experimental group was 33.33%,and the effective rate of the control group was 5.26%,and the efficacy of the experimental group was better than that of the control group(P<0.05),indicating that heat-sensitive moxibustion can effectively improve patients’ discomfort symptoms and improve the efficacy of traditional Chinese medicine.3.Quality of life score: On the 14 th day of chemotherapy,the quality of life score of both groups was significantly lower than that before chemotherapy(P<0.05),indicating that chemotherapy would reduce the quality of life of patients;However,the score of the experimental group was higher than that of the control group(P<0.05),indicating that heat-sensitive moxibustion can effectively improve the quality of life of patients after chemotherapy.4.Blood cell count: After treatment,intra-group comparison showed that on the14 th day of chemotherapy,blood cell count including white blood cell count,neutrophil count,hemoglobin count and platelet count were significantly decreased in both groups(P<0.05),indicating that chemotherapy could cause bone marrow suppression and lead to the decline of blood cells;On the 21 st day of chemotherapy,the blood cell count in both groups increased compared with the 14 th day of chemotherapy(P<0.05),indicating that the bone marrow recovered slowly on the 21 st day of chemotherapy,and the blood cell count increased slowly but was still at a low level.The comparison between groups showed that the blood cell count of the experimental group on the 14 th day and the 21 st day of chemotherapy was higher than that of the control group(P<0.05),indicating that heat-sensitive moxibustion can effectively reduce bone marrow suppression and promote bone marrow recovery.5.Comparison of blood transfusion during treatment: erythrocyte suspension infusion and platelet transfusion in the experimental group were lower than those in the control group during treatment.There was statistical significance in the amount of erythrocyte suspension infusion between the groups(P<0.05),indicating that thermo sensitive moxibustion can effectively reduce the amount of erythrocyte suspension infusion.There was no statistical significance in the amount of platelet transfusion between the two groups(P>0.05),indicating that thermo sensitive moxibustion had no obvious effect on the amount of platelet transfusion.Conclusions: Heat-sensitive moxibustion can improve the related discomfort symptoms of elderly patients with acute myeloid leukemia after chemotherapy,improve the quality of life of elderly patients with acute myeloid leukemia after chemotherapy,and effectively reduce bone marrow suppression after chemotherapy,reduce the amount of blood products;This observation shows that in addition to internal treatment of traditional Chinese medicine,Heat-sensitive moxibustion is also an effective means of chemotherapy intervention for elderly patients with acute myeloid leukemia. |
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