Clinical Study On Heat-sensitive Moxibustion In Treating The Type Of Qi-deficiency Cancer-related Fatigue

Objective:Through the clinical research on heat-sensitive moxibustion and traditional moxibustion in the treatment of patients with Qi-deficiency cancer-related fatigue（CRF）,it provides a reference for exploring the effective moxibustion program of CRF.Method:1.Grouping:60 CRF patients were randomly divided into heat-sensitive moxibustion group（observation group）and traditional moxibustion group（control group）,with 30 cases in each group.On the basis of routine symptomatic and supportive treatment,the two groups were selected for moxibustion at Guanyuan,Zusanli（bilateral）,and Shenque points.2.Operation method:Both groups of CRF patients fully exposed the surgical site and took a comfortable supine position.Heat-sensitive moxibustion group:According to the"Specifications for Heat-sensitive Moxibustion Techniques",first explore the heat-sensitive acupoints in Guanyuan,Zusanli（both sides）,and Shenque,and then select the best heat-sensitive acupoints for gentle moxibustion.Saturation desensitization moxibustion amount.Traditional moxibustion group:Gentle moxibustion was performed on Guanyuan,Zusanli（bilateral）,and Shenque points with ignited moxa sticks.The skin was warm without burning pain for 15 minutes per point.3.Course of treatment:Both groups of CRF patients were treated once/d,6d/week,2 weeks as a course of treatment,and a total of 4 weeks of treatment.The KPS score,PFS score,TCM Qi Deficiency Score,Mc Gill Quality of Life Scale score and immune cell level changes before and after treatment of the two groups of CRF patients were observed,and the differences in clinical efficacy between the two groups were compared.4.Statistical method:Use SPSS22.0 to conduct statistical analysis on the data collected in this subject research.Result:1.The general data（gender,age,course of disease,cancer type and cancer stage）of the two groups of CRF patients before treatment are statistically analyzed,and all P>0.05,indicating that the difference between the groups is not statistically significant and comparable.2.KPS score:（1）KPS score comparison between the two groups before treatment,P>0.05,there is no significant difference,and it is comparable.（2）The comparison of the KPS scores in the two groups before and after treatment,both P<0.05.After treatment,the KPS scores of the two groups were significantly higher than those before treatment,indicating that the patient’s living ability improved.Both heat-sensitive moxibustion and traditional moxibustion treatment can improve the patient Survival skills.（3）The comparison of KPS scores between the two groups after treatment,P<0.05,indicates that the difference in efficacy between the two groups is statistically significant,and the efficacy of heat-sensitive moxibustion in improving the life ability of CRF patients is better than that of traditional moxibustion.3.PFS score:（1）Comparison of PFS total score and behavior,mood,feeling,and cognitive dimensions between the two groups before treatment,all P>0.05,indicating that the difference is not statistically significant and comparable.（2）Comparison of PFS total scores and behavior,mood,feeling,and cognitive dimensions within and between the two groups before and after treatment,all P<0.05,the difference was statistically significant.The reduction of the PFS total score and the scores of various dimensions in the heat-sensitive moxibustion group was significantly better than that of the traditional moxibustion group,indicating that the heat-sensitive moxibustion therapy has better clinical effects in reducing CRF symptoms.（3）Grading of fatigue degree in the heat-sensitive moxibustion group before treatment:0 cases,7 cases,and 22 cases for mild,moderate,and severe;traditional moxibustion group:0 cases,10 cases for mild,moderate,and severe,respectively,20 cases,rank sum test,P>0.05,indicating that the difference between the two groups before treatment is not statistically significant and comparable.After treatment,the degree of fatigue is graded.The heat-sensitive moxibustion group:10cases,18 cases,and 1 case for mild,moderate,and severe;traditional moxibustion group:4 cases,22,and 4 for mild,moderate,and severe.For example,P<0.001,indicating that the fatigue degree of the two groups has been effectively improved after treatment.The heat-sensitive moxibustion group reduced fatigue of CRF patients better than the traditional moxibustion group.4.TCM syndrome score and total effective rate:（1）The score of TCM Qi-deficiency syndrome between the two groups before treatment,P>0.05,indicates that the difference between the two groups before treatment is not statistically significant and comparable.（2）Comparison of TCM Qi-deficiency syndrome scores in the two groups before and after treatment,both P<0.001,indicating that the TCM symptoms of the two groups were improved after treatment.After treatment,the scores of TCM Qi-deficiency syndromes between the two groups were compared,P<0.05.The TCM scores of TCM Qi-deficiency syndromes in the heat-sensitive moxibustion group decreased more significantly,indicating that the heat-sensitive moxibustion group is better than the traditional moxibustion group in treating patients with Qi-deficiency CRF.（3）In the heat-sensitive moxibustion group,7（24.14%）,16（55.17%）,3（10.34%）,3（10.34%）were clinically cured,markedly effective,effective,and ineffective.The total effective rate was 89.66%.Traditional moxibustion The number of clinically cured,markedly effective,effective and ineffective persons in the group was 2（6.67%）,12（40.00%）,9（30.00%）,7（23.33%）,and the total effective rate was76.67%.After testing,the difference in clinical total effective rate between the two groups was statistically significant（P<0.05）.It shows that the two groups have better curative effect on the treatment of TCM Qi deficiency syndrome.5.Mc Gill quality of life scale score:（1）Before treatment,the scores of quality of life,physiology,psychology,personal existence,social support,rank sum test between the two groups were all P>0.05,indicating that the difference was not statistically significant and comparable.（2）Comparison of the quality of life scores,physical,psychological,personal existence,social support dimensions,rank sum test within and between the two groups before and after treatment,all P<0.05,indicating that the quality of life of the two groups has been improved,and the heat sensitivity The effect of moxibustion in improving the quality of life of patients was significantly better than that of the traditional moxibustion group.6.Changes in immune cell levels:（1）Comparison of the levels of immune cells between the two groups before treatment was P>0.05,which was not statistically significant and comparable.（2）Comparison of the percentage of immune cells in the traditional moxibustion group before and after treatment within the group,the changes in CD₄⁺,CD₈⁺,and CD₄⁺/CD₈⁺levels P>0.05,indicating that the effect is not obvious.The heat-sensitive moxibustion group compared before and after treatment within the group,both P<0.05,there is a significant difference,heat-sensitive moxibustion treatment increased the patient’s immune cell CD₃⁺,CD₄⁺,CD₄⁺/CD₈⁺level,lowered the CD₈⁺level,and promoted the improvement of the patient’s immune function.After treatment,the comparison between the two groups was P<0.05,indicating that the heat-sensitive moxibustion group adjusted the level of immune cells significantly and could effectively improve the immune function.In conclusion:1.Both heat-sensitive moxibustion and traditional moxibustion for CRF can improve patients’living ability,reduce fatigue symptoms,improve quality of life and enhance immune function,but the effect of heat-sensitive moxibustion is better than traditional moxibustion.2.The curative effect of thermal moxibustion on CRF is satisfactory and it is worthy of clinical application.