Study On The Correlation Between CCL20 And Selenoprotein P And The Degree Of Coronary Artery Disease

Objective: The purpose of this study was to investigate the correlation between the serum concentrations of CC chemokine ligand 20(CCL20)and selenoprotein P in the study group and the degree of coronary artery stenosis.To further understand the related factors of coronary artery disease and select more valuable new factors for the prevention and treatment of coronary heart disease.Research Methods:1.A total of 80 patients who underwent coronary angiography in the Department of Cardiology of our hospital from August 2019 to November 2020 were selected as subjects.One team for coronary angiography examination and cardiology,by two or more experts to assess the LM、LAD、LCX and RCA have lesions or more than 50%(50 cases),collect the coronary angiography results,count record pathological changes,on the basis of Gensini score calculate a score for each patient,According to the number of lesions,the patients were further divided into single-vessel group(20 cases),double-vessel group(16 cases)and threevessel group(14 cases).According to Gensini score,29 cases were divided into low group(< 45),and 21 cases were divided into high group(≥45).In the normal group,there were 30 cases with coronary angiography without stenosis.2.Fasting cubital vein blood was collected from all subjects in the morning,general information of patients was recorded,and liver and kidney function,blood routine and blood lipid were collected.Serum levels of CCl20 and Selenoprotein P were determined.Results:1.Compared with the general data of the normal group,there was no statistical significance in gender,hypertension and smoking between the two groups(P >0.05).2.There were statistically significant differences in TC,HDL,LDL,UA and WBC between the two groups(P < 0.05).There were no significant differences in age,TG,Cr,cystatin C,PLT,Hb,RDW-CV(%)between the two groups(P > 0.05).3.Comparison of general data between the study groups showed that there were no statistically significant differences in TC,LDL,HDL,UA and WBC between the lesion count group and the Ginsini rating group(P > 0.05).4.Compared with the normal group,the level of CCl20 in the study group was significantly increased(P< 0.01),and the level of Selenoprotein P was significantly decreased(P < 0.01).5.lesion count CCL20 between groups,the level of selenoprotein P was difference was statistically significant(P < 0.05),the comparison between single and double branch group CCL20 and selenoprotein P level difference was statistically significant(P < 0.05),between the single and three groups CCL20 and selenoprotein P level difference was statistically significant(P < 0.05),more than CCL20,comparison of selenoprotein P difference between groups have no statistical significance(P > 0.05).There were statistically significant differences in CCL20 and selenoprotein P levels between the low and high Gensini groups(P < 0.01).6.In the study group,CCL20 level was positively correlated with Gensini score(r=0.409,P < 0.01);Selenoprotein P level was negatively correlated with Gensini score(r=-0.474,P < 0.01).Conclusion:1.The serum concentrations of CCL20 and selenoprotein P were different between the study group and the normal group.These results suggest that both CCL20 and selenoprotein P may be involved in the occurrence and development of coronary artery diseases.2.Serum CCL20 concentration in the study group was positively correlated with Gensini score,which may be one of the factors accelerating the development of coronary atherosclerosis.Serum selenoprotein P concentration was negatively correlated with Gensini score.It may be one of the factors inhibiting the progression of coronary atherosclerosis.