| Objective:To guide the clinical practice better,we analyze the literature of traditional Chinese medicine(TCM)about hematuria-based on IgA nephropathy(IgAN)by applying association rule and uncover the law of TCM syndrome and the characteristics of Chinese Materia Medica.Methods:First of all,according to the inclusion and exclusion criteria,we strictly screened literatures about hematuria-based on IgAN after searching those in the database of China National Knowledge Infrastructure(CNKI),Chian Info,VIP and Pubmed.Secondly,before conducting the frequency analysis of syndrome and drug characteristics,we standardized the drug names and syndrome types in the literatures to establish a database.Finally,we applied association rules to analyze the relationship of composition of herbs and common syndrom.Results:1.There were 51 literatures,including 33 syndromes,and more common ones of which were blood stasis,dampness-heat and qi-yin deficiency in the study.2.139 prescriptions were found in the standard literatures,and by one tally,the number of herb and its occurrence times was 177,869 respectively.Thereinto,that the occurrences of the Chinese herbal medicine were 20 times or higher included nine traditional Chinese medicines,namely,Huangqi,Common cephalanoplos herb,Lalang grass rhizome,Dried rehmannia root,Herba ecliptae,Yam,Rubia cordifolia,Poria cocos and Dansen.3.By viewing the literatures,we summed all the herbs up and found that they belonged to16 kinds of Chinese medicines in the research,which based on tonic drugs,hemostyptic,heat-clearing drugs,damp-clearing drug,blood-activatingand stasis-resol.They were sweet,bitter,pungent in taste,cold,plat,warm in nature,and mainly attributive to the liver,lung,kidney,heart,spleen meridians.4.According to Apriori algorithm,the following conclusions were drawn: we obtained eight medicinal herbs with strong correlation with blood stasis syndrome,namely,Lalang grass rhizome,Prepared rehmannia root,Huangqi,Common cephalanoplos herb,Herba ecliptae,Yam,Danshen and Poria cocos by setting the minimum support degree to 5.0% and the minimum confidence degree to 50.0%;at the same time,seven medicinal herbs with strong correlation with dampness-heat syndrome were acquired,that is,Lalang grass rhizome,Huangqi,Common cephalanoplos herb,Dried rehmannia root,Herba ecliptae,Typha angustifolia and Rubia cordifolia by making the minimum support degree to 10.0% and the minimum confidence degree to 50.0%;besides,nine medicinal herbs with strong correlation with qi-yin deficiency were got,namely,Huangqi,Lalang grass rhizome,Yam,Common cephalanoplos herb,Rubia cordifolia,Dried rehmannia root,Radix glycyrrhizae,Herba ecliptae and Poria cocos by defining the minimum support degree as 20.0% and the minimum confidence degree as 50.0%.Conclusions:1.Nine medicinal herbs such as Huangqi,Common cephalanoplos herb,Lalang grass rhizome are the major drugs to treat hematuria–based on IgA nephropathy;furthermore,Huangqi and Yam(Lalang grass rhizome or Common cephalanoplos herb)combination,and Poria cocos and Atractylodes macrocephala koidz,Rubia cordifolia,Huangqi combination are more relatively frequent herb combinations of treating the disease,which indicates that the clinical treatment of hemuresis-based on IgA nephropathy is primarily comprised of remedy deficiency,hemostasis,heat clearing,water benefit and dampness,and blood stasis drugs.2.That the chief syndromes of hematuria-based on IgA nephropathy consist of blood stasis,dampness-heat,and qi-yin deficiency syndrome.In addition,that the number of medicinal herbs on curing syndromes mentioned above are eight,seven and nine respectively. |
