| Objective:To scientifically evaluate the clinical efficacy and safety of traditional Chinese medicine collapse therapy combined with meibomian gland massage in the treatment of Meibomain Gland Dysfunction dry eye,to provide a new method for external treatment of traditional Chinese Medicine in the treatment of Meibomain Gland Dysfunction dry eye.To establish a standardized clinical trial protocol for Meibomain Gland Dysfunction dry eye.Mining and sorting out the new concept of traditional Chinese medicine in the treatment of Meibomain Gland Dysfunction dry eye,enrich the theory of traditional Chinese medicine in the treatment of eye diseases.Methods:This study is a prospective,randomized,parallel control study.In this study,sixty patients with meibomian gland dysfunction dry eye who met the inclusion criteria and exclusion criteria were selected and randomly assigned to the treatment group and the control group according to 1:1.The control group was given meibomian gland massage and sodium hyaluronate eye drops.Meibomian gland massage was given once a week,and sodium hyaluronate eye drops was given four times a day,one drop each time.The course of treatment was four weeks.On the basis of the control group,the treatment group was given traditional Chinese medicine collapse treatment,three times a week,once every other day,twenty minutes each time,for four weeks.The general data of this study included gender,age and course of disease;Results the efficacy indexes included the change of subjective symptom score compared with baseline at the 2nd and 4th week,Tear Breakup-up Time compared with baseline at the 2nd and 4th week,Cornea Fluorescein Staining compared with baseline at the 2nd and 4th week,Schirmer I Test compared with baseline at the 2nd and 4th week,eyelid margin and meibomian gland opening compared with baseline at the 2nd and 4th week,eyelid ester character compared with baseline at the 2nd and 4th week,difficulty degree of eyelid ester excretion compared with baseline at the 2nd and 4th week,and safety evaluation.Results:A total of sixty patients with Meibomain Gland Dysfunction dry eye were included in this study,and two patients lost.A total of fifty-eight patients(one hundred and sixteen eyes)completed the treatment for four weeks.There were thirty cases(sixty eyes)in the treatment group and twenty-eight cases(fifty-six eyes)in the control group.1.There was no statistical difference in gender,age,course of disease,subjective symptoms,Tear Breakup-up Time,Cornea Fluorescein Staining,Schirmer I Test,eyelid margin and meibomian gland opening,meibomian ester traits,and emission difficulty degree of eyelid ester between the two groups of subjects at baseline(P>0.05).2.The changes of subjective symptom scores of the two groups after two and four weeks of treatment compared with the baseline:After two and four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05);After two weeks of treatment,there was no significant difference between the two groups(P>0.05);After four weeks of treatment,there was no significant difference between the two groups(P>0.05).3.The changes of Tear Breakup-up Time of the two groups after two and four weeks of treatment compared with the baseline:After two and four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05);After two weeks of treatment,there was no significant difference between the two groups(P>0.05);After four weeks of treatment,there was significant difference between the two groups(P<0.05).4.The changes of Cornea Fluorescein Staining of the two groups after two and four weeks of treatment compared with the baseline:After two and four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05);After two weeks of treatment,there was no significant difference between the two groups(P>0.05);After four weeks of treatment,there was no significant difference between the two groups(P>0.05).5.The changes of Schirmer I Test of the two groups after two and four weeks of treatment compared with the baseline:After two and four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05);After two weeks of treatment,there was no significant difference between the two groups(P>0.05);After four weeks of treatment,there was significant difference between the two groups(P<0.05).6.The changes of eyelid margin and meibomian gland opening of the two groups after two and four weeks of treatment compared with the baseline:After two and four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05);After two weeks of treatment,there was no significant difference between the two groups(P>0.05);After four weeks of treatment,there was no significant difference between the two groups(P>0.05).7.The changes of eyelid ester character of the two groups after two and four weeks of treatment compared with the baseline:After two weeks of treatment,there was no significant difference between the two groups(P>0.05),the difference in the treatment group and the control group were no statistically significant compared with the baseline(P>0.05).After four weeks of treatment,there was significant difference between the two groups(P<0.05),the difference in the treatment group was statistically significant compared with the baseline(P<0.05),the difference in the treatment group was no statistically significant compared with the baseline(P>0.05).8.The changes of difficulty degree of eyelid ester excretion of the two groups after two and four weeks of treatment compared with the baseline:After two weeks of treatment,there was no significant difference between the two groups(P>0.05),the difference in the treatment group was statistically significant compared with the baseline(P<0.05),the difference in the treatment group was no statistically significant compared with the baseline(P>0.05).After four weeks of treatment,the difference in the treatment group and the control group was statistically significant compared with the baseline(P<0.05),there was significant difference between the two groups(P<0.05).9.There were no adverse reactions and adverse events in the two groups,which were safe and reliable.Conclusion:1.Traditional Chinese medicine Collapse therapy combined with meibomian gland massage can effectively improve Tear Breakup-up Time,increase tear secretion,improve the character of palpebral ester,and promote the discharge of palpebral ester.2.There was a certain improvement trend in subjective symptoms,Cornea Fluorescein Staining,palpebral margin and meibomian gland opening,but there was no statistical significance.3.Traditional Chinese medicine Collapse therapy combined with meibomian gland massage in the treatment of Meibomain Gland Dysfunction related dry eye has high compliance,good safety,no adverse reactions and adverse events. |
