Investigation Of Clinical Efficacy Of Qingrexiefei Decoction In The Treatment Of Sepsis With Heat Toxin Accumulating In The Lung

Objective: To evaluate the effect of Qingre xiefei Decoction on sepsis by observing the symptoms,signs,inflammation related indexes,D-dimer,lactic acid,gastrointestinal dysfunction score,Murray lung injury score,sequential organ failure score,acute physiology and chronic health score,and TCM syndrome score Objective to investigate the clinical effect of heat toxin accumulation in lung syndrome and its mechanism,so as to provide new ideas and methods for the treatment of sepsis.Methods: the patients who met the inclusion criteria were randomly divided into the experimental group and the control group,30 cases in each group.They were given conventional western medicine treatment,and the experimental group was treated with Qingre xiefei decoction.The course of treatment was7 days.After treatment,the symptoms,signs,inflammation related indicators,D-dimer,LAC,gastrointestinal dysfunction score,Murray lung injury score,SOFA score,APACHE II score and TCM syndrome score of the two groups were observed and recorded,and the statistical analysis and discussion were conducted.Results: 1.There was no significant difference in age,gender,WBC,neutrophil percentage,C-reactive protein(CRP),procalcitonin(PCT),D-dimer,LAC,gastrointestinal dysfunction score,Murray lung injury score,SOFA score,APACHE II score and TCM syndrome score between the two groups before treatment(P > 0.05).2.After treatment,the WBC,neutrophil percentage,CRP,PCT,D-dimer of the two groups were lower than before,and the difference was statistically significant(P < 0.05),and on the seventh day of treatment,the experimental group was lower than the control group,with statistical difference(P < 0.01);on the third day of treatment,there was no significant difference between the two groups(P > 0.05).On the third and seventh day of treatment,lac of the two groups were lower than before,and the experimental group was slightly lower than the control group,but there was no significant difference between the two groups(P > 0.05).After treatment,the gastrointestinal dysfunction score,Murray lung injury score,SOFA score,APACHE II score and TCM syndrome score of the two groups were lower than before(P < 0.05),and the experimental group was lower than the control group,with significant difference between the two groups(P < 0.05).In terms of the comprehensive efficacy of traditional Chinese medicine,the total effective rate of the experimental group was 73%,and that of the control group was 43%,with statistical difference(P < 0.05).Conclusion: the clinical effect of heat clearing and purging decoction combined with western medicine in the treatment of gastrointestinal dysfunction in patients with sepsis may be related to the underlying mechanism.