Discussion On The Medication Law Of Xu Zhiyin In The Treatment Of Non-hyperthyroidism Stage Of Hashimoto Thyroiditis Using Data Mining Method

Objective:Based on data mining method to explore Professor Xu Zhiyin’s clinical experience in the treatment of non-hyperthyroidism stage of Hashimoto thyroiditis.It mainly included the frequency,classification,and the nature,taste and meridian tropism of common drugs.Through the cluster analysis of core drugs,common drug pairs and drug association rules were obtained,the academic characteristics and experience of Professor Xu’s treatment of non-hyperthyroidism stage of Hashimoto thyroiditis were summarized,guiding clinical medication,improving the curative effect of syndrome differentiation and treatment,and providing basis for follow-up research.Methods:A total of 476 effective prescriptions meeting the inclusion criteria and exclusion criteria,for treatment of non-hyperthyroidism stage of Hashimoto thyroiditis in Outpatient department of Jiangsu Provincial Hospital of TCM from September 2018 to December 2020 were sorted.According to the Pharmacopoeia of the People’s Republic of China and the Synonym Dictionary of Chinese Herbs,the drug names were standardized and unified.The clinical drug database of Professor Xu was constructed by Microsoft Excel 2010,constructing data mining models such as clustering analysis and association rule analysis.The pathogenesis characteristics of Professor Xu’s treatment of non-hyperthyroidism stage of Hashimoto thyroiditis were analyzed with data mining method to analyze and summarize the treatment principles,treatment methods and clinical treatment plans.Results:Professor Xu Zhiyin’s 476 effective prescriptions for the treatment of Hashimoto’s thyroiditis in the non-hyperthyroid stage showed that a total of 55 male patients and 421 female patients were included,and the oldest was 79 years old,youngest was 16.The age of the patients was mainly 30-59 years old.A total of 156 drugs were used and the frequency of use was 7854 times;among the 32 drugs with a frequency of≥40,the top 10 drugs were:Moutan cortex,Red peony,licorice,pinellia,poria,tangerine peel,Turmeric,green peel,Radix Paeoniae Alba,Ephedra.156 commonly used medicines Chinese medicines were more warm and flat,and the tastes were mostly sweet,bitter,and pungent;the meridians were mostly liver,lung,and kidney meridians.25 flavors with high frequency,the clustering results of the drug system were:G1:Poria,Codonopsis,Licorice;G2:Aconite,Pinellia termata;G3:Tangerine peel,Atractylodes,Ephedra;G4:Red peony,green peel,Prunella vulgaris,Moutan peel,Turmeric;G5:Turmeric,Dipsacus,Rehmannia glutinosa;G6:Salvia miltiorrhiza,peach kernel,Morus sylvestris;G7:Tripterygium wilfordii,Radix Paeoniae Alba;G8:Antlers,Saponaria japonicus,Guizhi,Angelica.The first 6 groups of drugs with the strongest correlation between the two drugs Pairs were:Moutan bark-Red peony root,Moutan bark-White peony root,Pinellia-Tangerine peel,Poria-Tangerine peel,Tangerine peel-Turmeric,Moutan bark-Turmeric;the top 4 combinations with the strongest correlation among the three are:Mudan bark Compatible with Pinellia+red peony root,Mudanpi with turmeric+green peel,tangerine peel with Poria+Pinellia,red peony with white peony+Poria.Conclusion:Professor Xu Zhiyin’s clinical syndrome focuses on the combination,compounding,transformation,and evolution of pathogenesis during the progression of the disease.The treatment of Hashimoto’s thyroiditis in the non-hyperthyroid stage emphasizes soothing the liver,regulating qi and nourishing yin,so as to promote vitality and health.The spleen purifies phlegm and turbidity to dissipate blood stasis and evils,warms the kidney and replenishes qi to boost yang and promotes qi and blood,which improves the patient’s quality of life and has a positive effect.