Theory And Clinical Research On The Treatment Of Depression And Insomnia With Chaihu Plus Longgumuli Decoction

Objective:To further explore the theoretical basis of Chaihu plus Longgumuli Decoction in the treatment of depression with insomnia,analyze its characteristics,clarify its indications,and evaluate the effect of Chaihu plus Longgumuli Decoction in the treatment of depression with insomnia through clinical research.The curative effect provides a reference for further research on the clinical usage or preparation of Chaihu plus Longgumuli Decoction,and also provides new ideas for the treatment of other emotional related diseasesMethods:The theoretical part is based on the systematic review and analysis of Chaihu plus Longgumuli Decoction and its related theories,ancient and modern literatures related to depression and insomnia,and the latest theoretical research progress.The theoretical principles of traditional Chinese medicine for syndromes,combing the "Pivoting Shaoyang" treatment method from the perspective of the relationship between the viscera and fu organs,and establishing a system architecture of the viscera with Shaoyang cardinals as the core in the treatment of depression and other emotional diseases,and exploring its treatment of depression,The specific mechanism of insomnia at the viscera level,and attempts to expand the scope of its indications.According to the basic principles of clinical trial design,the clinical trial part collected 48 cases of depression patients,and randomly divided them into a treatment group of 24 cases and a control group of 24 cases.The treatment group was treated with the thick decoction of Chaihu plus Longgumuli Decoction,and the control group was treated with escitalopram oxalate plus eszolam/clonazepam.Both groups were treated for 4 weeks.Observe and record relevant scoring data before treatment,5 days,10 days,15 days,and 28 days after treatment.By comparing the statistical results of the Hamilton Depression Scale and Pittsburgh Sleep Scale before and after treatment,the clinical efficacy of Chaihu plus Longgumuli Decoction in the treatment of depression and insomnia was evaluated.Results:Comparison of the overall efficacy of depression:the treatment group was cured with 3 cases,markedly effective in 10 cases,effective in 8 cases,and ineffective in 3 cases,with a total effective rate of 87.2%;in the control group,there were 1 case,3 cases,13 cases,and 7 cases,with a total effective rate of 54.2%.After testing,the overall efficacy of the treatment group for depression is better than that of the control group(P<0.05),and the effect of improving insomnia is also better than that of the control group(P<0.05).Conclusion:The thick decoction of Chaihu plus Longgumuli Decoction can effectively improve the depressive symptoms of patients with depression and insomnia,and can also significantly improve the symptoms of insomnia.