| Objective: To observe the clinical efficacy and safety of Jianpishengshi Decoction in the treatment of spleen deficiency and dampness-block syndrome in gout remissive period by comparing febuxostat tablets with randomized control method,and to broaden the idea and method of clinical treatment of this disease.Methods: A total of 72 inpatients and outpatients in the Department of Rheumatology of the Affiliated Hospital of Changchun University of Chinese Medicine from January 2020 to January 2021 were selected in this study,which met the diagnostic criteria of gouty arthritis in remission stage,and the TCM syndrome differentiation was syndrome of spleen deficiency and dampness obstruction.The experimental group and the control group were divided according to the random number table.There were 36 cases in each group.Both groups adhered to the basic treatment plan.The control group was febuxostat tablet(40mg×14 tablets/box),once a day,1 tablet for each time.The treatment course of both groups was 12 weeks.The erythrocytic sedimentation rate,C-reactive protein,blood,urine routine,liver and kidney function,blood uric acid concentration,etc.of all patients before and after treatment were collected.The changes of TCM syndrome scores before and after treatment,the number of recurrent acute gout and the time of symptom remission after attack of patients were observed.The relevant data were collated and statistically analyzed.Results: 1.Comparison of inflammatory indexes(CRP,ESR): Compared with the results before and after treatment,the levels of C-reactive protein and ESR in 2 groups were significantly decreased(P < 0.01),with statistical significance.After 12 weeks of treatment,there was no significant difference in inflammatory indexes between the two groups(P >0.05).2.Blood uric acid concentration: by stage comparison within the group,the blood uric acid concentration of the patients at 4 weeks,8 weeks and 12 weeks of treatment was compared with that before treatment alone,and the blood uric acid concentration decreased significantly,with statistically significant difference(P < 0.01);At 4 and 8 weeks of treatment,there was no significant difference in serum uric acid concentration between the two groups(P BBB 0 0.05).After treatment,the serum uric acid level in experimental group decreased more significantly than that in control group,and the difference was significant(P < 0.05).3.Comparison of the number of acute gout attacks during the course of treatment: there was no statistical significance in the total incidence of acute gout between the two groups(P > 0.05),27.77% in the experimental group and 38.89% in the control group;After treatment,the number of acute gout attacks in 2 groups was significantly reduced,and the number of acute gout attacks in the third stage(8-12 weeks)was statistically significant compared with the number of acute gout attacks in the first stage(0-4 weeks)(P < 0.05).4.Comparison of pain relief time after acute gout attack during treatment:statistically,the pain relief time in the experimental group was 20.29±1.27(h)and that in the control group was 24.62±1.46(h),the difference was statistically significant(P < 0.05).5.Comparison of syndrome efficacy: After the treatment,there was a difference in total effective rate between the two groups,88.89% in the experimental group and 61.11% in the control group,and the difference was significant(P < 0.05).6.Comparison of TCM syndrome scores: syndrome scores in both groups decreased significantly before and after treatment,and the difference was statistically significant(P < 0.01);After the course of treatment,the syndrome score in the experimental group decreased more obviously than that in the control group,and the difference was of extremely significant statistical significance(P < 0.01).7.Comparison of safety: During the test,a total of 9 cases of ADR occurred,including 3 cases in the test group and 6 cases in the control group,with mild symptoms.The adverse reaction rate was 8.33% in the experimental group and 16.67% in the control group,and the difference was insignificant(P > 0.05).Conclusions: this study used the spleen wet permeability party treat gout remission(pixu(spleen deficient)wet resistance),found that the application of traditional Chinese medicine spleen permeability wet side of the patients in both the improvement of clinical symptoms,TCM syndrome integral and reduced in the course of the decline in the number of acute gouty arthritis,pain relief time shorten,etc.,using western medicine is obviously better than the effect of the cloth division of him.This indicates that Jianpi Shushi Decoction is effective,safe and reliable in treating spleen deficiency and dampness-block syndrome in gout remission period. |
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