| ObjectiveTo observe the clinical efficacy and safety of treatment of essential hypertension(EH)among young and middle-aged people with Tianma Zhiyun powder,and to explore its possible mechanism of action,in order to provide a more safe,effective and simple method for the prevention and treatment of EH with traditional Chinese medicine,and lay a certain foundation for the development of Chinese medicine in the treatment of EH.MethodsAccording to the inclusion criteria,72 young and middle-aged EH patients were randomly divided into observation group and control group,36 cases each.The patients in the control group were treated with conventional antihypertensive drugs(valsartan),and they were not allowed to take other traditional Chinese medicine or proprietary Chinese medicine during the trial.In the observation group,Tianma Zhiyun powder(15g/bag)was added on the basis of the control group,Patients in this group need to take the TCM twice a day with 100ml hot boiled water and 30g powder each time,with a 8-week treatment period.Blood pressure(24-sbp,24-dbp,pulse pressure difference),blood lipid(TC,TG,HDL-C,LDL-C),Hcy,CRP,cardiopulmonary exercise test results,SAS value and TCM syndrome score were observed and compared before and after treatment.Results①There was no significant difference between the two groups in age,gender,course of disease and therapeutic effect before treatment including 24-sbp,24-dbp,pulse pressure difference,TC,TG,HDL-C,LDL-C,Hcy,CRP,cardiopulmonary exercise test results,SAS value and TCM syndrome score(P>0.05);It shows that the general data of the two groups are similar andcomparable.②TCM syndrome scores:There were significant differences in both groups after treatment(P<0.01).There was a significant difference between the two groups(P<0.01).The observation group was superior to the control group,which showed that two groups can improve clinical symptoms of patients,but the effect of taking routine antihypertensive drugs combined with Tianma Zhiyun powder was more prominent.③Blood pressure:There were significant differences in both groups after treatment(P<0.01).And there was a significant difference between the two groups(P<0.01).The observation group was superior to the control group,indicating that the two treatment methods had significant antihypertensive effect,but the effect of conventional antihypertensive drugs combined with Tianma Zhiyun powder was more prominent.④Blood lipid:There were significant differences in both groups after treatment(P<0.01).And there was a significant difference between the two groups(P<0.01).Which indicating that valsartan could improve the levels of serum lipids(TC,TG,HDL-C,LDL-C)in patients with hypertension,and the combination of Tianma Zhiyun powder had a more obvious effect on lipid lowering.⑤Serum CRP level:There were significant differences in Serum CRP level both groups after treatment(P<0.01).And there was a significant difference between the two groups(P<0.01).The results showed that valsartan could partially improve the serum inflammatory level of patients with hypertension,and the combination of Chinese medicine Tianma Zhiyun powder had better effect.⑥Serum Hey level:There were significant differences in Serum Hey level both groups after treatment(P<0.01).And there was a significant difference between the two groups(P<0.01).The observation group was superior to the control group,indicating that Tianma Zhiyun powder could improve the serum Hey level of patients with hypertension and delay the damage of target organs.⑦Exercise tolerance:There were significant differences in AT,V02MAX,METS and exercise time after treatment in observation group(P<0.01).However,there was no significant difference in the control group after treatment(P>0.05).There was a significant difference between the two groups(P<0.01).The results showed that Tianma Zhiyun powder had a certain effect on the improvement of exercise tolerance,but valsartan did not.⑧Anxiety state:There were significant differences in anxiety state both groups after treatment(P<0.01).But there was no significant difference between the two groups(P>0.05).The results showed that Tianma Zhiyun powder had no significant antianxiety effect,which was different from the expectation.⑨Overall efficacy:6 cases fell off after treatment.10 cases were cured in the treatment group,16 cases were markedly effective,6cases were effective,1 case was ineffective,and the total effective rate was 96.97%.in the control group,30 cases were cured in 0 cases,significantly effective in 8 cases,effective in 19 cases,ineffective in 6 cases,with a total effective rate of 81.81%.There was a significant difference between the two groups(P<0.01),indicating that Tianma Zhiyun powder combined with conventional antihypertensive drugs had better effect on young and middle-aged EH patients with phlegm and blood stasis.ConclusionTianma Zhiyun powder has a better therapeutic effect on young and middle-aged EH patients with Phlegm Blood Stasis Syndrome.This method can not only improve the main clinical symptoms and blood pressure level of the patients,but also regulate the blood lipid(TC,TG,LDL-C,HDL-C)level,serum CRP and Hcy level of the patients,improve the exercise tolerance of the patients,and the overall effect is significantly better than that of the patients treated with western medicine alone. |
