| Background and aim:Chronic atrophic gastritis(CAG)is a common clinical disease of the digestive system with multiple pathogenic factors which has been accepted as precancerous lesions.Previously,moxibustion has been proved to be an effective treatment for CAG.Moxibustion acting on the skin of acupoints treats CAG,however the underlying mechanism of this beneficial treatment is not clear yet.Methods:In the present study,an integrated histopathological examination along with 1H NMR analysis of multiple biological samples(skin,brain,gut,stomach and serum)were employed to systematically assess the pathology of CAG and therapeutic effect of moxibustion at Liangmen(ST 21)and Zusanli(ST 36)acupoints located in the stomach meridian of C AG model rat.Results and conclusions:Moxibustion first produced aspartate and adenosine in the skin,indicating the occurrence of neurotransmitter-related metabolism.The increase in glucose and lactate in the brain suggests that these brain fuels supply the raw material for the transmission of neurotransmitters in the central nervous system.In the gut,the production of glycerophosphocholine can act on the gastric mucosa and help neurotransmitters transmission,which showed the therapeutic effect of moxibustion on CAG.This study further verified the metabolic changes of the stomach and serum.Moxibustion restored the levels of gastric glucose and glutamine to normal,which indicated that moxibustion could restore gastric energy and protein metabolism on CAG rats.Besides,pathological observation showed that moxibustion could ameliorate the damaged gastric mucosa of CAG rats.It also regulated immune-related metabolism through the change of serine and glutamine in serum.Conclusions:Moxibustion plays a therapeutic role in chronic atrophic gastritis through the connection of gut-brain-skin axis.These findings provided a new insight into the mechanism of moxibustion in the treatment of CAG. |
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