Over a fifteen year period, Patient Reported Outcomes ("PRO") applications to support over forty clinical and research projects have driven the evolution of an open-source computerized PRO system ("cPRO", http://cprohealth.org). The projects varied widely in PRO content, clinical domain, and workflows. Detailed case studies of six major implementations of the cPRO system offer a framework to understand the socio-technical challenges and opportunities in collecting computerized PROs and incorporating PROs into clinical care, patient-centered tools, and research. |