| Background and purposeSkin is the largest organ of the human body,which is the primary barrier against the attack of many physical,chemical and biological factors.However,with the development of the economy and the increasing demand for industry and agriculture,environmental problems such as greenhouse effect,depletion of the ozone layer,light pollution and smog weather are emerging endless.Especially,the destruction of the ozone layer causes an increase in the amount of ultraviolet radiation.Long time of exposure to UV light can cause a variety of skin lesions,such as erythema,sunburn,aging,photosensitivity skin disease and even skin cancer.Therefore,good skin barrier is an important factor in terms of maintaining good health condition.Polymorphic light eruption(known as rishaichuang in Chinese medicine)is a common photosensitive skin disease,which is a photoallergic reaction in the human body after exposure to sunlight.Chinese medicine believes it is mainly caused by patient's congenital endowment or the body's damp heat,combined with the not well-kept skin condition and poisonous of the sun in the spring and summer.The internal and external pathology factors gather on the skin surface and further cause stagnation and excessive heat.Polymorphic light eruption often causes severe discomfort to the patient,influences the patient's physical and mental health and affects their quality of life.To date,there is neither effective Chinese medicinal therapy nor established Western medicine treatment is available for the relieving of symptoms and the repairs of skin barrier The development of western medicine has objective factors such as consuming large amount of time and financial investment,while traditional Chinese medicine addresses the original cause of skin diseases and applies drugs according to the pathology,with the advantages including strong pertinence and small side effects.The ancient book outlined"the internal treatment for the inside,the external treatment for the outside" and"harmonized the external".Skin problem is an visual disease,which can be addressed by drugs applied directly to the disease,with the advantages of reducing the damage of liver and kidney function.Therefore,it is necessary to develop a simple and effective TCM external treatment approach for polymorphic light eruption.Artemisia-sinensis remove macula decoction was created by the dermatology department of Beijing Chinese Medicine Hospital,Zhao Bingnan,and was adjusted by several other specialists.The previous research of this research group found the effectives of internal application of Artemisia-Gentiana remove macula decoction on photosensitive dermatosis.However,due to the inconvenience of the internal treatment method and the need of oral administration of TCM in treating skin diseases,a new treatment method of external use of Artemisia-Gentiana remove macula decoction was adopted in the research.Therefore,the purpose of this study was to evaluate the clinical efficacy and the safety of the external use of Artemisia-Gentiana remove macula decoction in the treatment of polymorphic light eruption,and provide new thoughts for finding the external treatment with good efficacy and reasonable price.MethodPatients with polymorphic light eruption,who were admitted to the dermatology clinic of Beijing Chinese Medicine Hospital from July 2017 to March 2019,were intake into this research.A randomized,self-bilateral control method was applied to prescribe treatment for patients with post-sun repair cream containing Artemisia-Gentiana remove macula decoction(treatment group)and vitamin E cream(control group).Patients were evaluated before treatment and 1 to 4' weeks after treatment regarding overall treatment efficacy(EASI),skin barrier parameter,the severity of disease(TSS),itching severity(NRS),VISIA complexion analysis,disease controlling ability of patients,quality of life and the treatment safety.T-test were utilized to statistically analyze the differences between two groups.Results1.A total of 60 patients were included in the study with the male to female ratio of 1:3;and the ?45 years old.45 years old to 59 years old,?60 years old age ratio of 34:21:5.2.At the end of the treatment process(week 4),the EASI score,TSS score and NRS score of the intervention group was significantly lower than the control group(p<0.05);and each score showed a gradual decline during the whole treatment process.The water content of the stratum corneum of the patients from interventional group was significantly higher than that of the control group at each treatment process(p<0.05).3.The quality of life indicators and TCM clinical symptom scores after treatment were significantly lower than those assessed before treatment(p<0.05).There was no significant difference between the patients in the treatment group and the control group in terms of patients' disease controlling and tolerance ability(p<0.05).ConclusionIn this study,young and middle-aged female are mainly affected patients,consistent with the epidemiological trend.External use of Artemisia-Gentiana remove macula decoction to treat polymorphic light eruption can address patients' itching symptom and other skin lesions.Patient also demonstrated well tolerance for the treatment throughout the whole process.Restricted to factors such as sample size and treatment duration,the results outlined above need further verification by expanding the sample size and extending the treatment time frame. |
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