The Expression And Clinical Significance Of Serum Gastrin 17 In Gastric Cancer And Precancerous Diseases

Object:The incidence of gastric cancer in China is on the rise,and the mortality rate is high,which is the main problem that threatens human health.Detection of gastric cancer and precancerous disease G-17 level of serum gastrin and Helicobacter pylori expression,compared the serum level of G-17 and H.pylori infection in gastric cancer and precancerous diseases in the change of the level of serum G-17 and H.pylori infection with gastric cancer and precancerous diseases the expression and clinical significance in early prediction,its clinical application value in gastric cancer.Methods:Enzyme linked immunosorbent assay and 14 C breath test were used to detect serum G-17 level and H.pylori in 150 cases of gastric cancer and precancerous diseases.The difference of serum G-17 level and H.pylori infection among the groups was analyzed and compared.Results:1)disease correlation between serum G-17 levels and gastric cancer and precancerous gastritis: comparison group and non atrophy,G-17 level of gastric ulcer group and gastric polyp group and gastric cancer group increased significantly(P<0.05);compared with atrophic gastritis group,significantly increased in serum G-17 expression in gastric ulcer group and gastric polyp group and in gastric carcinoma group(P<0.05);2)the level of serum G-17 and the correlation between H.pylori infection: in H.pylori negative patients compared with non atrophic gastritis;in non atrophic gastritis,gastric ulcer group and gastric polyp group,H.Pylori group of gastric cancer in patients with positive serum G-17 levels higher than H.Pylori negative patients(P<0.05).Conclusion: The level of serum G-17 and H.pylori infection are closely related to gastric cancer and precancerous disease.Early detection of combined serum G-17 levels and H.Pylori detection is of great clinical significance for high-risk population screening and diagnosis for gastric cancer and precancerous diseases and early gastric cancer.