Observation On The Curative Effect Of Zishen Ningxin Method In Treating Menopausal Syndrome And The Correlation Between Psychological Stress And The Degree Of Symptoms

Objective1 To observe the improvement of clinical symptoms of cardiorenal disjunction type Menopausal Syndrome(MS)by nourishing kidney and tranquilizing heart method.2 To observe the effect of nourishing kidney and tranquilizing heart therapy on sleep symptoms in patients with cardiorenal disjunction MS.3 To observe the psychological stress of MS patients(including life events,emotional experience,coping styles)and its correlation with the severity of MS symptoms and sleep quality.MethodThe study patients were from March 2017 to December 2018 in the Beijing University of Traditional Chinese Medicine,the gynecological clinic of Dongzhimen Hospital.According to the diagnostic criteria of MS related Chinese medicine and Western medicine,and excluding the corresponding cases,30 cases of MS patients with heart-kidney disj unction type were selected according to the relevant criteria.Before treatment,Psychological Stress Survey for Group(PSSG),Modified Kupperman scoring Index(KI),Traditional Chinese Medicine syndrome score(TCM),Pittsburgh Sleep Quality Index(PSQI)were filled in to observe the degree of psychological stress and its correlation with the condition of menopausal syndrome and sleep quality.Oral medication was given for 8 weeks as a course of study.After treatment,the Modified KI,TCM syndrome score and PSQI were filled in to observe the improvement of symptoms before and after treatment.Result1 Comprehensive efficacy:30 cases,fully recovered in 3 cases(10%),markedly effective in 10 cases(33.3%),effective in 14 cases(46.67%),ineffective in 3 cases(10%),the total effective rate was 90%.2 The modified Kupperman score results:the standard deviation of mean score decreased from 27.13(+7.964)to 11.50(+8.577)before and after treatment,and the difference was significant(P<0.01).3 TCM symptom score results:The standard deviation of the mean score decreased from 19.13(+4.981)to 9.63(+5.732),with significant difference between before and after treatment(P<0.01).4 PSQI Score Results:The standard deviation of the mean score decreased from 12.87(+4.049)to 6.20(+3.872),with significant difference before and after treatment(P<0.01).5 The correlation between psychological stress and symptomatic degree of MS:There was no significant difference in the total number of life events and negative emotions between mild,moderate and severe groups(P>0.05);in the total score of negative coping,there was significant difference between mild group,moderate group and severe group(P<0.05),but there was no difference between moderate group and severe group(P<0.05).There was no significant difference between mild group and moderate group in total stress score(P>0.05),but there was significant difference between mild group and severe group,moderate group and severe group(P<0.05).There was significant difference in KI score between high stress group and low stress group(P<0.05).6 The correlation between psychological stress and sleep quality:There was significant difference between the negative coping score and the total stress score between the general sleep quality group and the poor sleep quality group(P<0.05);there was no significant difference in the total number of life events,negative emotions,positive emotions and positive coping between the two groups(P>0.05).There was no significant difference in sleep quality index between high stress group and low stress group(P>0.05).Conclusion1 Clinical research shows that nourishing kidney and tranquilizing heart therapy is effective in treating MS,and can significantly improve the clinical symptoms and sleep quality of patients with heart-kidney disjunction type MS.2 Psychological stress is correlated with the symptoms and sleep quality of MS,especially the total scores of negative coping and stress.