Analysis Of The Clinical Therapeutic Effect And Related Factors In ¹³¹I Treatment Of Graves' Disease In The Border Area Of Guangxi,Yunnan And Guizhou

Objective:To investigate the effect of ¹³¹I on Graves'disease?GD?and its related factors in the border areas of Guangxi,Yunnan and Guizhou provinces.To optimize and improve these factors,to offer guidelines for clinical individualized program selection,and also hope to obtain higher cure rate and the best cure effect through the combination of clinical research.Methods:A total of 277 graves patients treated with ¹³¹I in The Affiliated Hospital of Youjiang Medical University for Nationalities were collected.Their sex,age,course of hyperthyroidism,whether to use anti hyperthyroidism drugs,history of drug withdrawal,iodine uptake rate of thyroid,thyroid nodule in B ultrasound were recorded.Thyroid hormone including free triiodothyronine?FT3?,free thyroxine?FT4?,thyroid stimulating hormone?TSH?,thyroid autoantibody including anti thyroglobulin antibody?TGAb?,anti thyroid microsomal antibody?TMAb?,thyroid peroxidase antibody?TPOAb?,thyrotropin receptor antibody?TRAb?.Follow-up 6 months after making ¹³¹I remedy,assess the therapeutic effect,and divide it into efficacious,unhealed,and hypothyroidism.Thereby to analyze and conclude the relevant factors of the impact of ¹³¹I treatment.Results:?1?Among 277 patients with Graves'disease,155 cases were effective,the effective rate was 55.96%,66 cases were not cured,23.83%,56 cases were hypothyroidism,20.22%.?2?Univariate analysis showed that iodine uptake rate in 2-hours radioactive iodine uptake,thyroid weight,iodine treatment amount,drug withdrawal history and exophthalmos were the related factors that affected the clinical efficacy of hyperthyroidism ¹³¹I treatment,and the differences were statistically significant?P<0.05?.Gender,age,course of disease,history of ATD treatment,goiter,thyroid nodule,24-hour iodine uptake rate,FT3,FT4,TSH,TGAb had no significant difference with the efficacy?P>0.05?.?3?Logistic regression analysis outcomes:The weight of thyroid gland and exophthalmos were the major factors affecting the curative effect.No exophthalmos?or=0.035,95%CI=0.296?0.968,P=0.039?and less thyroid weight?or=1.017,95%CI=1.002?1.032,P=0.022?were found in patients with effective treatment.Conclusion:1.Findings of this study Graves'disease selection ¹³¹I,the overall effective rate of treatment was 76.18%,the curative effect was ideal within 6 months.2.The patients with Graves'disease with exophthalmos and thyroid gland weight were less cured by ¹³¹I treatment,which indicated that exophthalmos and thyroid weight were the adverse factors of¹³¹I treatment for Graves'disease.