| Research background:Bi Qiu is a disease characterized by paroxysmal and recurrent episodes of nasal itching,sneezing,and runny nose.It is otolaryngology common disease,frequently-occurring diseases.Modern medicine allergic rhinitis,vasomotor rhinitis,eosinophils in diseases such as allergic rhinitis can be reference for syndrome differentiation and treatment of the disease,including clinical are the most common allergic rhinitis.AR is an allergic disease of type I mediated by Ig E.The disease is easy to recur,delay and difficult to recover,and complications.With the aggravation of environmental pollution,people's living pressure increases and their immunity decreases,the incidence of AR is increasing,and AR has become a health problem that urgently needs to be paid attention to and solved.At present,modern medical treatment of AR mainly consists of drug therapy and immunotherapy.Among them,drug treatment can quickly relieve the symptoms in the short term,but the long-term effect is not good.Immunotherapy for Ig E mediated ? model for the treatment of allergic disease,very possible to "cure" AR is presented,but immunotherapy long and complicated process,high economic costs,adverse reactions,compliance is difficult to guarantee,clinical application is limited.The Chinese medicine has a long history and profound understanding of this disease.Combining the holistic concept with syndrome differentiation and treatment,it has unique advantages in prevention and treatment of AR.At present,It is an obvious trend to apply traditional Chinese medicine or integrated Chinese and western medicine to treat AR.The first affiliated hospital of tianjin medical university,director of otolaryngology qiao fengying professors engaged in otolaryngology of traditional Chinese medicine clinical and scientific research and teaching more than 30 years,she has accumulated rich experience in treatment of allergic rhinitis,think the allergic rhinitis disease from lung and spleen.The nose is an orifice outside the lungs,with abundant pulmonary energy and coordinated propaganda,salvation and descent,so that the function of the orifice can be exerted normally.The spleen is the biochemical source of Qi and blood,and the normal function of the nose cannot be separated from the Qi,blood and body fluid derived from the spleen and soil.The lung belongs to gold and the spleen belongs to earth.Lung and spleen are the viscera of children and mothers,and the pathological changes of the two viscera and organs can affect and change each other.The children steal the mother's Qi or the mother's disease and their children,which eventually leads to deficiency of both lungs and spleen,unstable guard surface,invasion of pathogens of wind,cold and foreign qi,and nose snoring.Therefore,the method of invigorating the lung,invigorating the spleen and dredging Qiao is used as a guide to treat Bi Qiu of lung-spleen deficiency type,and the clinical effect is remarkable.I followed my tutor professor qiao fengying to study for three years,and learned and summarized her experience in the treatment of Snoring with deficiency of lung and spleen by means of syndrome differentiation and syndrome differentiation,and conducted further clinical research and discussion Objective: to investigate the clinical curative effect of invigorating lung and spleen for treating Allergic rhinitis.Methods: From January to December 2019,120 patients who diagnosed as Bi Qiu of lung-spleen deficiency were treated in the Otolaryngology Department of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine.This patients were randomly divided into control group and treatment group,with 60 cases in each group,according to their visiting date and the order of visiting on that day.The control group was treated with fluticasone propionate nasal spray(Glaxo Smith Kline,imported drug registration number H20140117,specification 50 ug/spray),1 spray/side,2 times/day;the treatment group,on the basis of the control group,cooperated with Bufei Jianpi Tongqiao method,prepared Bufei Jianpi Tongqiao recipe(drug composition: roasted Astragalus 15 g,Fangfeng 10g).10 g of fried Atractylodes macrocephala,6 g of fried licorice,10 g of Angelica sinensis,10 g of orange peel,5 g of cohosh,10 g of Poria cocos,10 g of Xanthium,10 g of Hinoyi,10 g of Angelica dahurica,6 g of mint,10 g of Schisandra chinensis,10 g of Wumei and 10 g of earthworm)were treated with 150 ml/time,2 times/day.Both groups were treated continuously for 4 weeks,and the curative effect was observed after 2 weeks and 4 weeks of treatment,respectively.Result:(1)There were 2 lost cases in the treatment group and 1 lost cases in the control group.(2)The investigation on the surrounding environment and family history of 117 patients in this study showed that decoration accounted for 22.22%,tobacco exposure accounted for 56.41%,keeping pets accounted for 23.07%,planting flowers and plants accounted for 14.52%,automobile exhaust exposure,dust and chemical environment accounted for 20.51%.The incidence of AR in mothers was 27.35%,in fathers 23.93%,in parents 41.88% and in parents 6.83%.(3)After 2 weeks of treatment,23 cases in the treatment group showed positive effects,22 cases were effective,and 13 cases were ineffective,with a total effective rate of 77.58%.In the control group,12 cases were markedly effective and 21 cases were effective.,26 cases were ineffective The total effective rate was 55.93%.The difference was statistically significant(P < 0.05).After 4 weeks of treatment,30 cases in the treatment group were markedly effective,19 cases were effective,9 cases were ineffective,and the total effective rate was 84.48%.In the control group,15 cases were markedly effective,23 cases were effective and 21 cases were ineffective.The total effective rate was 64.40%.The difference was statistically significant(P < 0.05).The treatment group was better than the control group.(4)After 2 weeks and 4 weeks of treatment,the scores of nasal symptoms and signs in both groups were lower than before treatment,and the difference was statistically significant(P < 0.05).After 2 weeks of treatment,the scores of nasal obstruction,runny nose and physical signs in the treatment group and the control group were compared,and the difference between the two groups was statistically significant(P < 0.05).The treatment group was superior to the control group.After 4 weeks of treatment,the scores of sneeze,runny nose,nasal congestion,nasal itch and physical signs were compared between the treatment group and the control group,and the treatment group was better than the control group.Statistical analysis showed that the difference between the two groups was statistically significant(P < 0.05).(5)After 2 weeks of treatment and 4 weeks of treatment,the scores of TCM syndromes were lower in the treatment group than before treatment,and the difference was statistically significant(P < 0.05).After 2 weeks of treatment,the scores of each complication in the control group were compared with those before treatment,and the difference was not statistically significant(P < 0.05).After 4 weeks of treatment,the scores of head coma in the control group were compared with those before treatment,and the difference was statistically significant(P < 0.05).After 2 weeks of treatment,the scores of the treatment group and the control group in the head coma were compared,the treatment group was better than the control group,and the difference between the two groups was statistically significant(P < 0.05).After 4 weeks of treatment,the scores of head drowsiness,limb drowsiness,tolerance and loose stool in the treatment group and the control group were compared.According to statistical analysis,the scores of the treatment group were better than those of the control group,and the difference between the two groups was statistically significant(P < 0.05).(6)Observation of the relationship between gender and efficacy in the treatment group showed that there were 27 male patients,13 with obvious efficacy,11 with effective efficacy and 3 with ineffective efficacy.Among the 31 female patients,17 were effective,8 were effective and 6 were ineffective.After statistical analysis,the difference was not statistically significant(P>0.05).(7)In the observation of the relationship between age and efficacy in the treatment group,there were 25 patients aged 18-33 years old,among whom 14 were significantly effective,9 were effective,and 2 were ineffective.There were 26 patients aged 34-49 years old,among which 13 were effective,8 were effective and 5 were ineffective.There were 7 patients aged from 50 to 65 years old,of which 3 were effective,2 were effective and 2 were ineffective.After statistical analysis,the difference was not statistically significant(P>0.05).(8)The relationship between the course of disease and the curative effect was observed in the treatment group.The course of disease was 2-4 years in 23 patients,16 patients showed obvious effects,5 patients were effective,and 2 patients were ineffective.Among the 25 patients with disease course of 5-7 years,12 were effective,11 were effective and 3 were ineffective.Among the 9 patients whose course of disease was more than 8 years,2 were effective,3 were effective and 4 were ineffective.After statistical analysis,the difference was statistically significant(P<0.05).Conclusion:(1)The surrounding environment and family history of AR patients are closely related to the incidence of AR.(2)The therapeutic effect of Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray on snoring of lung-spleen deficiency type was better than that of the control group.(3)Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray in the treatment of snoring of lung-spleen deficiency type was superior to the control group in the improvement of sneezing,runny nose,nasal obstruction,rhinitis and signs.(4)Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray in the treatment of pulmonary and spleen-qi deficiency snoring was superior to the control group in the improvement of dizziness,limb burnout,poor appetite and loose stool.(5)Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray in the treatment of snoring of lung-spleen deficiency type,the gender difference between the two groups has no correlation with clinical efficacy.(6)Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray in the treatment of snoring of lung-spleen deficiency type,the difference of age between the two groups has no correlation with clinical efficacy.Young and middle-aged people are the main population with high incidence.(7)Bufei Jianpi Tongqiao method combined with fluticasone propionate nasal spray in the treatment of snoring of lung and spleen-qi deficiency type,the shorter the course of disease,the better the efficacy. |
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