Analysis Of The Correlation Between Helicobacter Pylori Infection And Non-alcoholic Fatty Liver Disease

Objective: To explore the relationship between Helicobacter pylori(H.pylori)infection and(NAFLD)in non-alcoholic fatty liver,and to analyze the potential mediators of H.pylori infection in the pathogenesis of NAFLD,so as to provide a new strategy for the prevention and treatment of NAFLD.Methods: Using the method of cross-sectional investigation,we collected the people who were examined by carbon 14 urea breath test and abdominal color ultrasound at the same time from January 2018 to December 2018 at the Mei Nien Health examination Institution in Yinchuan,Ningxia.According to the inclusion and exclusion criteria and the method of random sampling,3947 subjects who met the criteria were included in the study.According to whether they had NAFLD,or not,they were divided into NAFLD(-)group(n = 2987)and NAFLD(+)group(n =960).The general information of the two groups(sex,age),BMI,SBP,DBP,FPG,TC,TG,HDLC,LDL-C,AST,ALT,UA,white blood cell count and H.pylori infection were statistically analyzed.Then the statistically significant indexes of the above factors were included in the binary Logistic regression analysis of the risk factors affecting NAFLD.At the same time,the effects of H.pylori infection on BMI were analyzed in different sex,age and NAFLD stratification.In addition,according to the situation of H.pylori infection,all the people were divided into H.pylori positive group(n = 2081)and H.pylori negative group(n = 1866).The risk factors related to NAFLD in the two groups were compared to further analyze the potential mediators that may mediate the pathogenesis between the two groups.Results:(1)A total of 3947 subjects were studied,including 2022 males and 1925 females.The number of H.pylori infection in all physical examination subjects was 2081(52.72%).The number of),NAFLD patients was 960(24.32%).(2)After statistical analysis of the data of NAFLD(-)group and NAFLD(+)group,it was found that there were significant differences in sex,SBP,DBP,BMI,FPG,TC,TG,HDL-C,LDL-C,AST,UA and leukocyte count between the two groups.HDL-C level in NAFLD(+)group was lower than that in NAFLD(-)group,while SBP,DBP,BMI,FPG,TC,TG,LDL-C,AST,UA and leukocyte count were higher than those in NAFLD(-)group.According to the data analysis of H.pylori infection and NAFLD prevalence,it was found that the prevalence of NAFLD in H.pylori positive group was higher than that inH.pylori negative group,and the difference was statistically significant(P<0.001).Gender,DBP,BMI,FPG,TG,HDL-C,LDL-C,AST,UA and H.pylori were the main risk factors of NAFLD after the above meaningful indexes were included in binary logistic analysis.After stratified analysis of sex,age and BMI,H.pylori was still a risk factor for NAFLD.(3)The relationship between H.pylori infection and risk factors of NAFLD was further compared.Analysis showed that the level of HDL-C in the H.pylori positive group was lower than that in the H.pylori negative group,while the serum TG,LDL-C,FPG and leukocyte count in the H.pylori negative group were higher than those in the H.pylori negative group.There were significant differences in the abovementioned indexes between the two groups(P<0.05).(4)The relationship between H.pylori infection and NAFLD in people with dyslipidemia was analyzed,and it was concluded that people with dyslipidemia complicated with H.pylori infection were more likely to suffer from NAFLD(P<0.001).Conclusion: 1.H.pylori infection is related to the increased risk of NAFLD.2.H.pylori infection may participate in the occurrence of NAFLD by affecting the metabolism of blood lipids.3.The inflammatory response mediated by H.pylori infection may be involved in the pathogenesis of NAFLD.