Association Between Non-Alcoholic Fatty Liver Disease And Helicobacter Pylori Infection

Objectives Through the epidemiological investigation in health physical examination population to get the prevalence rates of Non-alcoholic fatty liver disease(NAFLD) and Helicobacter pylori(HP) infection,NAFLD related risk factors were also discussed,and the correlation of NAFLD and its related factors with Hp infection was evaluated to provide a theoretical basis for the prevention of N AFLD and Hp infection and to provide references for clinical treatment and prevention.Methods By the descriptive study method of cross-sectional investigation, the health physical examination people in Shanghai Tongren Hospital from October 2013 to October 2014 were screened to study the correlation between NAFLD and Hp infection with the method of random sampling. The ultrasound scan of liver and the detection of BMI、TG,TC,HDL-C,LDL-C,VLDL-C,FFA,hs-CRP、FPG and the serum antibody of HP were done properly. The database was established with Epidata 3 software and the data were analyzed by SPSS19.0 statistical software. For continuous variables, the results were shown as mean ± standard deviation(x— + SD); classification variables were shown as the number of cases(percentage(N);%). The measurement data were compared by Test of Z with the large sample, the numeration data were analyzed by chi square test, multiple factors Logistic regression analysis with two classification was used to analyze the association of Hp infection and its related factors, the correlation and trend analyses between the rate of positive serum Hp antibody and different factors were done by Mantel-Haenszel test. Standard test is significant to take the bilateral alpha =0.05, P < 0.05 was defined as statistical significance.Results 1. 2650 cases were investigated altogether, and none was lost. 687 cases(25.92%) were diagnosed as NAFLD which include 462 cases of male(39.52%) and 255 cases of women(15.19%), while the other 1963 cases were excluded from NAFLD; There were positive Serum Hp antibody in 579 cases, which included 327 male cases(27.97%) and 252 female cases(17.02%), the other 2071 cases(78.15%)were Hp antibody negative. The prevalence rate of N AFLD in Hp antibody positive group(33.85%) was significantly higher than that in Hp antibody negative group(23.71%)by statistic(p<0.05).2. There were correlations between hp infection and the factors such as diagnosed NAFLD, BMI, TG, TC, HDL-C, LDL-C, VLDL-C, FFA, hs-CRP, FPG and ESR without any revisions. With revisions by age and sex, there were still correlations between hp infection and the factors such as diagnosed NAFLD, BMI, TC, LDL-C, VLDL-C, FFA, hs-CRP, FPG and ESR. With revisions by gender, age, systolic blood pressure, diastolic blood pressure, there were still correlations between hp infection and the factors such as diagnosed NAFLD, BMI, TC, LDL-C, VLDL-C, FPG and ESR.3. There were significant correlations between the rate of positive Hp antibody and the growth trend of diagnosed NAFLD, BMI, TC, LDL-C, VLDL-C, FPG and ESR without any revisions(p-trend≤0.005). With revisions by gender, age, systolic blood pressure, diastolic blood pressure, there were no correlations between the rate of positive Hp antibody and the growth trend of BMI, TC and LDL-C(p>0.05),while the correlations were significant between the rate of positive Hp antibody and the growth trend of VLDL-C, FPG and ESR(p<0.05)Conclusions The prevalence rate of NAFLD in people with positive serum Hp antibody was significantly higher than those without serum Hp antibody, with the remarkable differences in related high risk factors of NAFLD between the two groups at the same time. Diagnosed NAFLD, BMI, TC, LDL-C, VLDL-C, FPG and ESR were all correlated with Hp infection significantly, the rate of positive Hp antibody were correlated with the growth trend of VLDL-C, FPG and ESR. Hp infection may be involved in the pathophysiological process of NAFLD.